Recurrence at Nipple Areola Complex and Safety of Nipple-Sparing Mastectomy —Reply

In Reply We thank Han and Lee for their insightful comments regarding our article. As Han and Lee suggest, we agree that the analysis of distant metastasis (DM) –free survival might include selection bias because the patients with cancer recurrence at the nipple-areola complex (NAC) as the first event had already survived for a long duration without DM before being assigned to the recurrence group. Nevertheless, in our study, of the 39 patients who experi enced recurrence at the NAC as the first event, 2 developed subsequent DM (5.1%). Meanwhile, of the 923 patients who did not experience recurrence at the NAC as the first event, 48 developed DM (5.2%). The DM rates of these 2 groups were almost equal. Furthermore, all patients with cancer recurrence at the NAC as the first event survived with a mean follow-up duration of 51 months (range, 5-121 months) after NAC removal. It seems reasonable to conclude that patients with cancer recurrence at the NAC can have an excellent prognosis after appropriate treatment.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research

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Authors: Montagna G, Morrow M Abstract IntroductionThe contralateral prophylactic mastectomy (CPM) rate in the U.S. has been steadily increasing. This is of particular concern because many women who undergo this procedure are candidates for breast-conserving surgery.Areas covered: CPM's medical benefit is related to the risk of contralateral cancer development and whether CPM provides a survival benefit. Contralateral cancer rates have decreased, and CPM does not provide a survival benefit. Other potential benefits of the procedure may be improved quality of life; these data are reviewed. Research efforts have been...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
AbstractFungating breast cancer (FBC) is a rare entity in developed nations. But this occurrence is not uncommon in our country. The aim of this study was to review clinico-pathologic profile and outcomes of FBC in a developing country. This retrospective study consisted of patients with FBC managed at our institute (Jan 2005 –Dec 2015). Clinico-pathologic profile, management details, and outcomes were analyzed. The Kaplan-Meier method was used to determine overall survival (OS). Log-rank test was performed to compare survival in various subgroups. Seventy-nine patients were detected to have FBC constituting 3.3% of ...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
: Robotic nipple sparing mastectomy (R-NSM) and immediate gel implant breast reconstruction (IGBR) in the management of breast cancer had comparable clinical outcome with conventional nipple sparing mastectomy (C-NSM) and IGBR. R-NSM was associated with favorable patients ’ satisfaction of aesthetic outcome, however, at the price of longer operation time and more medical expanse if compared with C-NSM.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
A 64-year old female with a history of a pulmonary embolism on rivaroxaban, breast cancer (mastectomy in 2013), hypertension, and diabetes presented for fatigue for one month. She had intermittent hemoptysis for six months. She was brought to the emergency department complaining of fatigue. Blood pressure was elevated to 165/75 mmHg. On exam, she appeared lethargic with pale conjunctiva and leg edema. She did not have a skin rash. Laboratory studies were significant for creatinine of 15.3 mg/dL, blood urine nitrogen 140 mg/dL, potassium 6.5 mEq/L.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Conditions:   Breast Cancer;   Mastectomy;   Ambulatory Care Intervention:   Procedure: total mastectomy Sponsors:   Centre Hospitalier Universitaire, Amiens;   Centre hospitalier de Beauvais;   Centre Hospitalier de Saint-Quentin Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewWe review the management for unaffectedBRCA1/2 mutation carriers and the local management of early-stage breast cancer.Recent FindingsFor unaffectedBRCA1/2 mutation carriers, surveillance includes annual magnetic resonance imaging (MRI) and mammogram (MG). Novel imaging modalities, including abbreviated protocol MRI, ultrafast/accelerated MRI, and contrast-enhanced digital mammography are being investigated. Risk-reducing mastectomy (RRM) should be considered, and nipple-areolar sparing mastectomy (NSM) is now an option. Additionally, risk-reducing salpingo-oophorectomy (RRSO) is strongly recommend...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
Conclusion: Our initial report shows that NSM with immediate reconstruction may successfully be performed through periareolar incision. This method maximizes esthetic effects and may be an appropriate surgical option for NSM. PMID: 32051813 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
This study confirms the potentialities of both shaped micro-textured and round smooth implants in reconstructive surgery.
Source: Updates in Surgery - Category: Surgery Source Type: research
Conditions:   Breast Cancer;   Mastectomy;   Ambulatory Care Intervention:   Procedure: total mastectomy Sponsors:   Centre Hospitalier Universitaire, Amiens;   Centre hospitalier de Beauvais;   Centre Hospitalier de Saint-Quentin Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract BACKGROUND AND PURPOSE: There is limited retrospective evidence addressing the utility of post-mastectomy radiotherapy (PMRT) in patients with T3N0 breast cancer. We performed a retrospective analysis of the National Cancer Database (NCDB) comparing overall survival (OS) in T3N0 patients treated with mastectomy alone (MTX) or with PMRT. MATERIALS AND METHODS: We performed a matched-cohort analysis of NCDB breast cancer patients with pT3N0 disease who did not receive NAC, or cT3N0 patients who received NAC treated between 2006 and 2014. Patients were matched for all available baseline characteristics ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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