The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease.

The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease. Int Heart J. 2020 Jan 17;: Authors: Huang M, Zheng J, Chen Z, You C, Huang Q Abstract Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research

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Conclusions: The development of a pheochromocytoma from an adrenal non functional adenoma is an extremely rare event, but potentially life-threating because of the catecholamine-associated cardiovascular toxicity. In particular, TTS is a form of cardiomyopathy that has been increasingly described as associated with catecholamine-secreting tumors. The exclusion of pheochromocytoma in a patient with TTS has important therapeutic implications, since the administration of β-blockers may be extremely harmful in patients with catecholamine surge in the absence of adequate α-blockage.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractObesity and diabetes are risk factors for atrial cardiomyopathy and are, thus, deemed public health concerns. However, the effects of obesity on the left atrial (LA) function in patients with diabetes have not been determined yet. We sought to evaluate the effects of obesity on the LA function in patients with type 2 diabetes. Ninety-six consecutive patients with type 2 diabetes without significant coronary artery stenosis in selective coronary angiography were included in this cross-sectional study. Two-dimensional speckle-tracking echocardiography (2DSTE)-derived longitudinal LA myocardial deformation markers wer...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
This study demonstrates ongoing variability in the clinical management of SIC across Canada and illustrates a potential area for further research.RésuméMême si la cardiomyopathie de stress est de plus en plus reconnue, aucune étude contrôlée à répartition aléatoire n’a été réalisée ni aucune ligne directrice émise afin d’orienter la stratégie de traitement, et on en sait peu sur l’expérience à ce sujet au Canada. Cette étude visait à améliorer la compréhension de...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
The term Ischemic cardiomyopathy(ICM)  was originally coined by Dr. Burch from Tulane University, New Orleans, USA in 1970. For many decades there was skepticism regarding the existence of such entity. WHO classification over the years never included this term. ESC working group of 2008  (Elliott P,  European Heart 29(2):270–276) decided not to include CAD as a cause for cardiomyopathy. Even the current MOGES system doesn’t invoke CAD as a cause for cardiomyopathy.  But, I am sure, most of practicing cardiologists would agree, there is a need for such an entity. Why there is m...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Criteria and Nomenclature ischemic cardiomyopathy Uncategorized defintion of ischemic cardiomyopathy MOGES classification what is ischemic cardiomyopathy who whf classification of cardiomyopathy Source Type: blogs
This study demonstrates ongoing variability in the clinical management of SIC across Canada and illustrates a potential area for further research.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract AIM: To describe the coronary angiographic aspects observed in patients with dilated cardiomyopathies (DCM) in a sub-Saharan African country in order to improve their management. METHODS: This was a cross-sectional study conducted from 1 January 2010 to 31 March 2016. All patients aged 18 years and older, presenting with DCM and admitted to Abidjan Heart Institute, who underwent coronary angiography were included. One hundred and eight patients were selected. We analysed and compared the coronary angiographic features observed. RESULTS: The median age of our patients was 52 years (46-61). There ...
Source: Cardiovascular Journal of Africa - Category: Cardiology Authors: Tags: Cardiovasc J Afr Source Type: research
AbstractBackgroundThere are scanty data from India on the prevalence and clinical profile of cirrhotic cardiomyopathy (CCM).AimTo identify the prevalence and clinical presentation of CCM in patients with liver cirrhosis.MethodsFive hundred and eighty-six patients with liver cirrhosis were recruited based on inclusion criteria and evaluated for cardiac parameters using electrocardiography, 2-dimensional echocardiography, dobutamine stress test and coronary angiography as needed. Baseline demographic data, liver biochemistry, endoscopic and radiological findings were recorded in all the patients. Appropriate statistical anal...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionThe study showed a higher incidence of myocardial bridging then that of previous Indian studies. A significant proportion of patients presented with angina and acute coronary syndrome despite having no coronary artery disease. The incidence was higher in patients with hypertrophic cardiomyopathy whereas it was similar to that of general population in patients with rheumatic heart disease.
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
Authors: Iwaszczuk P, Kołodziejczyk B, Kruczek T, Drabik L, Płazak W, Komar M, Podolec P, Musiałek P Abstract BACKGROUND Neurogenic mechanism is believed to contribute to left ventricular (LV) systolic dysfunction in acute coronary syndromes (ACS); its extreme form is known as takotsubo cardiomyopathy. However, the magnitude of neurogenic contribution to LV dysfunction in all-comer first-time ACS remains unknown. MATERIAL AND METHODS In 120 consecutive patients with first-time ACS (age 66.3±12.3years, 40 women) coronary angiograms were individually matched to the echocardiographic left ventricular (LV) se...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion The study showed a higher incidence of myocardial bridging then that of previous Indian studies. A significant proportion of patients presented with angina and acute coronary syndrome despite having no coronary artery disease. The incidence was higher in patients with hypertrophic cardiomyopathy whereas it was similar to that of general population in patients with rheumatic heart disease.
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
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