BDNF-TrkB and proBDNF-p75NTR/sortilin signaling pathways are involved in mitochondria-mediated neuronal apoptosis in dorsal root ganglia after sciatic nerve transection.

CONCLUSION: proBDNF induced apoptosis in SGCs and sensory neurons in DRG following SNT. The proBDNF signaling pathway is a potential novel therapeutic target for reducing sensory neuron and SGC loss following peripheral nerve injury. PMID: 31957620 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31957620?dopt=Abstract

Source: CNS and Neurological Disorders Drug Targets - January 15, 2020 Category: Drugs & Pharmacology Authors: Wang X, Ma W, Wang T, Yang J, Wu Z, Liu K, Dai Y, Zang C, Liu W, Liu J, Liang Y, Guo J, Li L Tags: CNS Neurol Disord Drug Targets Source Type: research