Reverse innovation in practice: the Getting to Know Cerebral Palsy programme

Source: BMJ Comments - Category: General Medicine Source Type: forums

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In this study, we identified a novel microRNA-135b (miR-135b) in CP, and investigated its functional role in mediating NSC differentiation. CP models were established in Wistar rats and validated with the Y-maze test. Gain- and loss-of-function experimentation was performed on CP rats. Then NSCs were isolated and the expression patterns of miR-135b and S100B were altered in NSCs. S100B exhibited high expression in hippocampus tissues of CP models, which was targeted by miR-135b. miR-135b elevation or S100B silencing resulted in promoted NSC differentiation, alleviated brain injury and inhibited NSC apoptosis in hippocampus...
Source: Am J Physiol Cell Ph... - Category: Cytology Authors: Tags: Am J Physiol Cell Physiol Source Type: research
The insertion of a secondary task seems to interfere differently children with cerebral palsy, depending on the specific demands of each task. Thus, the importance of inserting dual tasks in the interventions is emphasized, considering that they are executed extensively in the day to day, and can act as facilitators or challenge in the execution of functional tasks.
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Source Type: research
ConclusionsGMs assessment at 3 mo post term could be considered as an important screening tool for early identification of VLBW infants who are at risk of neurodevelopmental impairment/cerebral palsy.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
While Botulinum NeuroToxin-A (BoNT-A) injections are frequently used to reduce the effects of hyperactive stretch reflexes in children with cerebral palsy (CP), the effects of this treatment vary strongly. Previous research, combining electromyography (EMG) with motion analysis, defined different patterns of stretch reflex muscle activation in muscles, those that reacted more to a change in velocity (velocity dependent –VD), and those that reacted more to a change in length (length dependent –LD). The aim of this study was to investigate the relation between the types of stretch reflex muscle activation in the ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conditions:   Posture Disorders in Children;   Cerebral Palsy Intervention:   Other: Photographic Posture Analysis Sponsor:   Baskent University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
It is crucial to interpret the fetal heart rate pattern with a focus on the pattern evolution during labor to estimate the relationship between cerebral palsy and delivery. However, nationwide data are lacking.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Obstetrics Source Type: research
AbstractTo examine the sleep habits of children with cerebral palsy  (CP) and use of night braces and to investigate their association with parental quality of life. The study included 114 children aged 3–6 (57 with typical development (TD) and 57 with CP). The children with CP were grouped according to the Gross Motor Function Classification System (GMFCS) and n ight brace use (NBU). “Children’s Sleep Habits Questionnaire-Abbreviated Form” and “Short-Form Health Survey” were used to investigate the children’s sleep habits and the parents’ quality of life, respectively. ...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
Plena inclusi ón (Full Inclusion) is Spain's leading NGO on Intellectual Disability and other Developmental Disabilities. It is made up of nearly 900 family-based non-profit organizations throughout the country. Full inclusion offers lifelong support to 140,000 people with Developmental Disabilities (DD) (Intell ectual Disability, Autism Spectrum Disorder and Cerebral Palsy) and their families.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Correspondence Source Type: research
Drooling, or sialorrhoea, is a common difficulty faced by children with neurological impairment including cerebral palsy. It may lead to a reduction in their quality of life, causing skin irritation, dehydration and high levels of embarrassment and social isolation for both the patient and family. This review will discuss the assessment of patients with sialorrhoea and potential management strategies including conservative management, medical options, botulinum toxin injections and surgery.
Source: Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Symposium: Cerebral Palsy Source Type: research
Intrathecal baclofen (ITB) is a well-recognised treatment option in the management of generalised spasticity and dystonia. Typically it is considered in children who have failed to respond to, or have not tolerated, appropriate enteral medications. Placement of a pump would be contraindicated in children who could not accommodate a pump due to size, or those who have a local or systemic infection. There are a number of relative contraindications which must be considered. An intrathecal baclofen test dose is usually advised and is particularly useful in screening for hypersensitivity.
Source: Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Symposium: Cerebral palsy Source Type: research
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