ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis Host Response and Inflammation

This study highlights ThPOK as a global regulator of immune function in which alterations may affect normal responses to infectious and inflammatory stimuli.
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research

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Zororo Makamba wasn’t supposed to die of the novel coronavirus. Not just because of his age, which at 30 placed him well out of the at-risk category for COVID-19 complications, but because of who he was. A well-known, pro-government media personality in Zimbabwe, and the son of a prominent business mogul, Makamba had the wealth and the connections that should have guaranteed him the best care possible. Instead, on March 23, Zimbabwe’s first confirmed case of the coronavirus died alone in a quarantined hospital, three days after his diagnosis. Hospital staff, lacking protective equipment, were afraid to come nea...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This article includes reporting by Ivet González in Havana, Mario Osava in Rio de Janeiro, and Orlando Milesi in Santiago. The post Latin America Has Weak Defences Against the Pandemic appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Editors' Choice Featured Headlines Health Human Rights Latin America & the Caribbean Population Regional Categories Coronavirus COVID-19 ECLAC Pan-American Health Organization (PAHO) Poverty World Health Organ Source Type: news
Authors: Godman B, McCabe H, D Leong T, Mueller D, Martin AP, Hoxha I, Mwita JC, Rwegerera GM, Massele A, Costa JO, do Nascimento RCRM, Lemos LLP, Tachkov K, Milushewa P, Patrick O, Niba LL, Laius O, Sefah I, Abdulsalim S, Soleymani F, Guantai AN, Achieng L, Oluka M, Jakupi A, Logviss K, Hassali MA, Kibuule D, Kalemeera F, Mubita M, Fadare J, Ogunleye OO, Saleem Z, Hussain S, Bochenek T, Mardare I, Alrasheedy AA, Furst J, Tomek D, Markovic-Pekovic V, Rampamba EM, Alfadl A, Amu AA, Matsebula Z, Phuong TNT, Thanh BN, Chichonyi Kalungia A, Zaranyika T, Masuka N, Olaru ID, Wale J, Hill R, Kurdi A, Timoney A, Campbell S, Meyer ...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Authors: Schlipköter U, Flahault A Abstract The past two centuries have seen enormous achievements in control of infectious diseases, previously the leading cause of death, in large measure due to sanitation and food safety, vaccines, antibiotics and improved nutrition. This has led people to put their faith in the notion that medical science would succeed in overcoming the remaining obstacles. Vaccination has eradicated smallpox, nearly eradicated poliomyelitis and greatly reduced many other highly dangerous infections such as diphtheria, tetanus and measles. New diseases such as HIV and new forms of influenz...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
ConclusionIn this analysis, we observed that 14% of SIV adults had LTBI, 27% of SIVH had at least one intestinal parasite, and about half of SIV children had EBLL. Most adults were susceptible to HBV. In general, prevalence of infection was higher for most conditions among Afghan SIVH compared to Iraqi SIVH. The Centers for Disease Control and Prevention (CDC)Guidelines for the US Domestic Medical Examination for Newly Arriving Refugees can assist state public health departments and clinicians in the care of SIVH during the domestic medical examination. Future analyses can explore other aspects of health among resettled SI...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsOur study found that standardized ID screening in a URM cohort was practicable and helped collection of relevant patient data in a thorough and time-effective manner. However, screening practices need to be ameliorated, especially in relation to testing for parasitic infections. Most importantly, we found that only a minority of infections were able to be detected clinically. This underscores the importance of active surveillance of IDs among refugees.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
[Global Fund] The Global Fund to Fight AIDS, Tuberculosis and Malaria welcomes the Japanese Diet's passage of the fiscal 2019 supplementary budget and the fiscal 2020 budget, which includes Japan's contribution of US$476.4 million to the Global Fund in 2020. This is its largest annual contribution to the Global Fund, signaling Japan's strong leadership in global health, at a time when the world is fighting COVID-19.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Thomson Reuters Foundation] London -Diseases like tuberculosis and malaria largely ravage low-income countries, with the situation made worse by poor nutrition and sanitation
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Abstract Ketol-acid reductoisomerase (KARI), the second enzyme in the branched-chain amino acid biosynthesis pathway, is a potential drug target for bacterial infections including Mycobacterium tuberculosis . Here, we have screened the Medicines for Malaria Venture Pathogen Box against purified M. tuberculosis ( Mt ) KARI and identified two compounds that have K i values below 200 nM. In Mt cell susceptibility assays one of these compounds exhibited an IC 50 value of 0.8 μM. Co-crystallization of this compound, 3-((methylsulfonyl)methyl)-2 H -benzo[ b ][1,4]oxazin-2-one (MMV553002), in complex with Staphylococc...
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research
This playground just outside the Slovak capital, Bratislava, has been sealed off to stop people spreading the virus. Similar measures are in place in cities and towns across Europe, which is now the epicentre of the virus's spread. Credit: Ed Holt/IPSBy Ed HoltBRASTISLAVA , Mar 16 2020 (IPS) Governments in wealthy, first world countries must not ignore the plight of poorer nations battling the coronavirus or the disease will not be brought under control, global development experts have said. As African nations slowly report growing numbers of cases, and more and more infections are registered in countries with endemic pove...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Development & Aid Editors' Choice Europe Featured Global Global Governance Headlines Health Humanitarian Emergencies IPS UN: Inside the Glasshouse Population Poverty & SDGs Regional Categories TerraViva United Nations Cor Source Type: news
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