AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor- β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway

In conclusion, inhibition of the CXCL12a/CXCR4 signaling axis maintained TIMP-3 expression via the PI3K/Akt pathway. Our findings provide insight into the mechanism by which AMD3100 prevents OA.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research