Negative impact of anesthesia with midazolam, sufentanil, and propofol used in pediatric flexible bronchoscopy on the tracheal ciliary beat frequency in guinea pigs

Publication date: Available online 22 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Marta Joskova, Peter Durdik, Martina Sutovska, Marian Grendar, Dusan Koniar, Libor Hargas, Peter Banovcin, Sona FranovaAbstractThere is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam) at a recommended doses administered individually or simultaneously on the tracheal ciliary beat frequency (CBF) in in vitro experimental conditions. Brush biopsy technique was used to remove the tracheal epithelia of guinea pigs for microscopy evaluation of ciliary beating monitored by high-speed video camera and analysed by Ciliary Analysis software. The tracheal CBF was significantly lower in the presence of sufentanil (10-8 mol/L) than in the control group; similarly for midazolam-sufentanil (10-8 - 10-5 mol/L), as well as for midazolam-propofol (10-5 and 10-3 mol/L) combinations. The fact that concurrent administration of benzodiazepine significantly increased the risk of sufentanil-induced cilia-inhibition was pharmacologically confirmed using GABAA receptor antagonist, bicuculline methiodide. The benefit of propofol on the potent cilia-inhibitory effect achieved by benzodiazepine-opioid combination was non-significant. We highli...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research

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Condition:   Lung Disorder Interventions:   Procedure: Anesthesia Procedure;   Procedure: Bronchoscopy Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In the January 2020 issue, the article “Venovenous Extracorporeal Membrane Oxygenation for Rigid Bronchoscopy and Carinal Tumor Resection in Decompensating Patients” (Hang D, Tawil JN, Fierro MA. Anesthesiology 2020; 132:156. doi: 10.1097/ALN.0000000000002967) failed to include an acknowledgment to a colleague who assisted with Panel B of the image, which gives important context to the CT image. The Acknowledgment should read: “The authors would like to acknowledge Jonathan S. Kurman, M.D., M.B.A., Department of Medicine, Division of Pulmonary and Critical Care, Medical College of Wisconsin (Milwaukee, Wi...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
AbstractHypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure at risk of deterioration of gas exchange, such as bronchoscopy). The European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) developed guidelines for the use of noninvasive respiratory support techniques in the hypoxaemic patient in the peri-operative and periprocedural period. The panel outlined five clinical questions regarding treatment with noninvasive respiratory support techniques [conventional oxygen therapy (COT),...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Hypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure with risk of deterioration of gas exchange, such as bronchoscopy). The European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) have developed guidelines for the use of noninvasive respiratory support techniques in the hypoxaemic patient in the peri-operative and periprocedural period. The panel outlined five clinical questions regarding treatment with noninvasive respiratory support techniques [conventional oxygen therapy (COT), ...
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Guidelines Source Type: research
No abstract available
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Correspondence Source Type: research
Response to comment on "Awake supraglottic airway guided flexible bronchoscopic intubation in patients with anticipated difficult airways: a case series and narrative review." Korean J Anesthesiol. 2020 Feb 28;: Authors: Wong P, Lim WY PMID: 32106640 [PubMed - as supplied by publisher]
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
Vaishali Waindeskar, Anuj JainJournal of Anaesthesiology Clinical Pharmacology 2020 36(1):131-133
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
ConclusionENB is a safe diagnostic procedure in an everyday setting with an acceptable diagnostic yield that offers a possibility to diagnose pulmonary nodules in patients for whom other diagnostic procedures are too hazardous or have proven unsuccessful.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 11 February 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Marc Kriege, Jan Dalberg, Brendan A. McGrath, Alexander Shimabukuro-Vornhagen, Björn Billgren, Thomas Kromann Lund, Klaus Thornberg, Alice Vangerschov Christophersen, Mark J.G. DunnAbstractBackgroundFlexible endoscopes have been well established for diagnostic and therapeutic interventions in critically ill patients. The purpose of this study was to compare the utility between the novel aScope 4 Broncho and the standard bronchoscope in a non-interventional study.MethodsIn a prospective multicentre study, we eva...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
ConclusionThe 1% tetracaine hydrochloride injection pure liquid aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia is effective and safe for bronchoscopy. This method of local anesthesia is worthy of clinical application.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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