Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients.

Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients. Cancer Biol Ther. 2020 Jan 20;:1-9 Authors: Ognibene M, Morini M, Garaventa A, Podestà M, Pezzolo A Abstract Patients with high-risk neuroblastoma (HR-NB) often initially respond to therapy, but afterward they become resistant and disease recurred. Unfortunately, it does not exist one or more specific chromosome defects associated with relapse or refractory NB. Recently, genomic evidence from primary tumors indicated that the distal region of chromosome 6q is loss in HR-NB patients with fatal outcome. We identified a minimal common region of loss of chromosome 6q27 spanning an area of 2.09 Mb by high-resolution DNA copy number data of a small cohort of HR-NB samples carrying 6q loss. This region of loss harbored five genes T, SFT2D1, RPS6KA2, FGFR1OP, and UNC93A. We found that low SFT2D1, RPS6KA2, and FGFR1OP gene expression predicted poor outcome in HR-NB patients using public R2 Platform. Further functional studies will be essential to confirm the presumed tumor suppressor gene(s) located within 6q27 region. These results suggest that SFT2D1, RPS6KA2, and FGFR1OP genes may be responsible for poor prognosis of HR-NB tumors with 6q27 loss, and their haploinsufficiency may be crucial in accelerating tumor progression. PMID: 31959052 [PubMed - as supplied by publisher]
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research

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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
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Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research
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Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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Source: EurekAlert! - Biology - Category: Biology Source Type: news
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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