GERD prevalence raised even in mild–moderate COPD, bronchiectasis

Researchers from Australia have found that the rate of gastroesophageal reflux disease is twice as high in patients with chronic obstructive pulmonary disease or bronchiectasis as in people without lung disease.
Source: MedWire News - Gastroenterology - Category: Gastroenterology Source Type: news

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Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett’s esophagus, and EAC. Methods: A case-control study from the UK General Practice Research Database was conducted. Cases were aged 50 or above with a diagnosis of COPD and were matched with controls without a diagnosis of COPD by age,...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
Conclusions: The prevalence of CC was lower than reported in previous studies. People with possible CC had higher rates of underlying conditions associated with CC. These observations may suggest poor recognition and/or under-recording of CC in primary care. PMID: 31558053 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Gastro-oesophageal reflux disease (GORD) and obesity are associated with frequent exacerbations and poor quality of life in people living with asthma. Multiple mechanisms have been proposed for the effect of obesity, including modification of inflammation affecting epithelial cell proliferation and wound repair, while the role of GORD is poorly understood and proton pump inhibitors (PPIs) are of variable efficacy. GORD might exert a deleterious effect by inducing vagal reflex, neuroinflammation and directly triggering airway inflammation (via microaspiration). Studies of reflux in animal models and human bronchial epitheli...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
The objective data comes from what you measure as an outcome. The device is the trainer. Again, use pressure threshold and then set out to measure the outcomes, a scale, a swallow exam, a cough flow rate, a voice quality, etc. Participant: How do you establish goals? There are norms for peak cough, is this what you use? Kiourkas: Respiratory uses cough peak flow to qualify for noninvasive ventilation for ALS and neuromuscular patients. The norms are different for each person. Suggested ranges are used as a guide to assist in determining if the patient is getting worse at subsequent visits. We also use a SNIP (sniffing pres...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Health Care Private Practice Schools Slider Speech-Language Pathology Dysphagia dyspnea muscle strength skilled nursing facility Swallowing Disorders Source Type: blogs
Semin Respir Crit Care Med 2018; 39: 667-673 DOI: 10.1055/s-0038-1676571Excessive central airway collapse (ECAC) is characterized by excessive narrowing of the airway lumen during exhalation leading to dyspnea, cough, mucostasis, recurrent respiratory infections, and poor quality of life. Tracheobronchomalacia and excessive dynamic airway collapse are heterogeneous entities of ECAC and are characterized by a diverse nonspecific symptom profile. Although the pathophysiology of airway mechanics as well as morphology in both entities is different, current evidence so far shows no practical benefit in making such distinction s...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
We present one of the rare presentations of aCML in an elderly patient.Case: A 76 year old male presented to the Hematology clinic for consultation after discharge from local hospital for elevated WBC count. Past medical history was significant for COPD, acid reflux, peripheral arterial disease and hypertension. Physical exam was unremarkable. Initial labs were significant for leukocytosis of 30 k/cu mm, anemia with Hb 10 gm/dl, thrombocytosis 695,000 with neutrophilia of ANC 25,200. Peripheral blood was negative for JAK2 V617F and BCR-ABL. Peripheral blood flow cytometry showed granulocytic left shift with 1.5% myeloblast...
Source: Blood - Category: Hematology Authors: Tags: 632. Chronic Myeloid Leukemia: Therapy Source Type: research
Conclusion: Our analyses suggest that comorbid condtions and theur treatment significantly affect mortality in various ILDs. Thus, comprehensive comorbidity assessment and management might be essential in all ILDs.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
Introduction: Many individuals with chronic obstructive pulmonary disease (COPD) report suffering from chronic pain, which is often underestimated by physicians. It could affect the patient’s quality of life.Aims and objectives: To determine common origins of chronic pain in individuals with COPD, its impact on their quality of life and its contribution to the emergence of anxiety and depression symptoms.Methods: A cross-sectional study of male individuals with COPD was conducted at the Pneumology Department of Hedi Chaker Hospital in Sfax (Tunisia) between January 10 and February 10 2018. Dyspnea severity was strati...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: These results suggest that most comorbid diseases do not affect severity, respiratory symptoms, exercise capacity, or quality of life, but osteoporosis is associated with more symptoms, worse exercise capacity, and poor respiratory-specific quality of life.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Study reveals a high prevalance of potentially treatable extra pulmonary and pulmonary comorbidities. We recommend a list of these treatable comorbidities be included as part of the standard work up of COPD patients undergoing CT as it would enable better patient outcomes.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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