Breast cancer stromal clotting activation (Tissue Factor and thrombin): A pre ‐invasive phenomena that is prognostic in invasion

ConclusionThis demonstrates procoagulant phenotypic changes occur in fibroblasts at the preinvasive stage. Fibroblast procoagulant phenotype is associated with aggressive breast cancer subtypes and reduced survival. Coagulation may be a therapeutic target in breast cancer.

Source: Cancer Medicine - January 20, 2020 Category: Cancer & Oncology Authors: Hudhaifah Shaker, Nigel J. Bundred, G öran Landberg, Susan A. Pritchard, Harith Albadry, Sarah L. Nicholson, Lauren J. Harries, Jing Y. E. Heah, John Castle, Cliona C. Kirwan Tags: ORIGINAL RESEARCH Source Type: research