Efficacy of ustekinumab versus advanced therapies for the treatment of moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Conclusions: Results indicate a higher likelihood of response, remission and endoscopic-mucosal healing at 1 year with UST versus comparators in the NBF population. In BF patients, a higher likelihood of response to UST versus most comparators was also observed, although results were more uncertain. PMID: 31960724 [PubMed - as supplied by publisher]
Condition: Ulcerative Colitis Intervention: Drug: tofacitinib Sponsor: Pfizer Not yet recruiting
(Wiley) Inflammatory bowel disease (IBD) -- including Crohn's disease and ulcerative colitis -- often affects women of childbearing age. A study published in Alimentary Pharmacology&Therapeutics compared the health of pregnant and non-pregnant women with IBD.
(Natural News) People suffering from ulcerative colitis can benefit from a plant compound found in red wine and chocolate. A recent study published in the Archives of Medical Research revealed that resveratrol can improve the quality of life of patients with ulcerative colitis. What is ulcerative colitis? Ulcerative colitis is a chronic disease that affects the inner...
Publication date: Available online 6 April 2020Source: Chemico-Biological InteractionsAuthor(s): Bo Dou, Wenji Hu, Minkai Song, Robert J. Lee, Xiaoyu Zhang, Di Wang
Day 1,364 of the COVID-19 quarantine (well, at least it feels like it). How are you holding up? If you’re like most people, you’re not having much fun. But if you already struggle with anxiety, depression or another mental health issue, these days of isolation and uncertainty can feel like absolute torture. In today’s Not Crazy episode, Gabe laments the loss of his routine — those regular activities he clung to religiously to keep his mental health in check. Now what is he supposed to do? Tune in for a special quarantine episode. Together, we will grieve our old routines and discuss...
ConclusionNon-adherence to mesalamine was underestimated by physicians in pregnant UC patients and contributed to disease relapse and possibly on pregnancy outcomes. Preconceptional education regarding safety of medications and risk of self-discontinuation is warranted.
ConclusionIn Crohn's disease, intestinal diversion may be considered in patient and disease specific scenarios and in ulcerative colitis, the use of a 3-stage approach to an ileal pouch is now more often used.
AbstractThe effect of TNF-blockers on T-lymphocyte subsets is largely unknown in inflammatory bowel diseases (IBDs). The aim of the present study was to analyze the prevalence of T-cell subtypes and their correlation to therapeutic response. Sixty-eight patients with Crohn ’s disease (CD), 46 with ulcerative colitis (UC) were enrolled. (1) The clinical course was followed after the initiation of TNF-blockers (prospective study). (2) The immunophenotype was also compared between long-term anti-TNF treated-responders and non-responders (cross-sectional study). The res ults were compared with those of therapy-naïve...
Conclusions: In this large IBD trial bureau, inflammatory bowel disease patients were very satisfied with the quality of care. Domains for quality improvement, such as attention to the impact of IBD on family and work, were identified. PMID: 32233268 [PubMed - in process]