The biochemical basis of interactions between Glucocerebrosidase and alpha ‐synuclein in GBA1 mutation carriers

AbstractThe discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes,GBA1 is one of the most common and well ‐studied, but it is still unclear how mutations inGBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship betweenGBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway.

Source: Journal of Neurochemistry - January 21, 2020 Category: Neuroscience Authors: M. Toffoli, L. Smith, A.H.V. Schapira Tags: REVIEW Source Type: research