Global REACH: Assessment of Brady-Arrhythmias in Andeans and Lowlanders During Apnea at 4330 m

Background: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e., Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent arrhythmogenesis at altitude, though this has not been documented in other High altitude groups, including those diagnosed with chronic mountain sickness (CMS). We investigated whether healthy (CMS-) and CMS afflicted (CMS +) Andeans exhibit cardiac arrhythmias under acute apneic stress at altitude.Methods and Results: Electrocardiograms (lead II) were collected in CMS- (N = 9), CMS + (N = 8), and Lowlanders (N = 13) following several days at 4330 m (Cerro de Pasco, Peru). ECG rhythm and HR were assessed at both rest and during maximal volitional apnea. Both CMS- and CMS + had similar basal HR (69 ± 8 beats/min vs. 62 ± 11 beats/min), while basal HR was higher in Lowlanders (77 ± 18 beats/min; P
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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AbstractPurposeEarly detection of cardiac arrhythmias is a major opportunity for mobile health, as wearable devices nowadays available can detect single-lead electrocardiogram (ECG). The study aims to validate the in-ear region as a new anatomical site for ECG signal detection and looks towards designing innovative ECG wearable devices.MethodsWe performed ECG using KardiaMobile device (AliveCor ®) on 35 healthy volunteers. First, ECG was detected by standard modality using both hands. Then, ECG was detected using the left in-ear region instead of the right hand. All the recorded ECGs were analyzed by the device and by ...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Conclusions In this trial, there does not appear to be a significant difference in electrocardiographic changes in patients with Brugada syndrome when propofolversus etomidate were administered for induction of anesthesia. This study did not investigate electrocardiographic changes related to propofol used as an infusion for maintenance of anesthesia, so future studies would be warranted before conclusions about safety of propofol infusions in patients with Brugada syndrome can be determined.Editor ’s PerspectiveWhat We Already Know about This TopicBrugada syndrome is an inherited cardiac ion channel disorder that pl...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
AbstractThe heart is an important muscular organ of the human body which pumps blood throughout the body. It is essential for human life. Timely and accurate assessment of the functioning of the heart has great relevance for reducing the death rate due to cardiac diseases around the world. If the heart is not able to pump blood smoothly, then heart diseases are likely to appear. These heart diseases are known as arrhythmia. Electrocardiogram (ECG) is a diagnostic tool for assessing the functioning of heart non-invasively. It not only detects cardiovascular diseases, but also examines breathing pattern and mental stress. EC...
Source: Sensing and Imaging - Category: Biomedical Engineering Source Type: research
Abstract Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated ion channel genes with co-expression in brain and heart have been proposed as SUDEP candidate genes since they provide a singular unifying link between seizures and lethal cardiac arrhythmias. Here, we generated a conditional knockout (cKO) mouse with neuron-specific deletion of Kcna1, a SUDEP-associated gene with brain-heart co-expression, to test whether seizure-evoked cardiac arrhythmias and SUDEP require the absence of Kv1.1 in...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
This study is divided into two stages: (a) a systematic review carried out following the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) statement in six databases, in order to identify the features of the PPG signal reported in the literature for the detection of AF, and (b) an experimental evaluation of them, using machine learning, in order to determine which have the greatest influence on the process of detecting AF. Forty-four features were found when analyzing the signal in the time, frequency, or time–frequency domains. From those 44 feat...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: January 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issue 1Author(s): M. Drissa, H. Jamila, H. DrissaBackgroundAtrial septal defect (ASD) is one of the most common causes of congenital heart disease manifested in adulthood and a subgroup of patients may not develop symptoms until late adulthood.Aim of studyThe aim of our study was to describe clinical and likelihood picture of adults over 60 years born with an ASD type II.MethodsWe performed a retrospective analysis of adult's ASD referred to our institution from 2010 through 2018. Clinical, electrocardiographic, echocardiograp...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
This study could be beneficial for researchers to analyze the existing state-of-art techniques used in detection of arrhythmia conditions.
Source: IRBM - Category: Biomedical Engineering Source Type: research
Publication date: Available online 31 December 2019Source: Artificial Intelligence in MedicineAuthor(s): Arun Kumar Sangaiah, Maheswari Arumugam, Gui-Bin BianAbstractThe recognition of cardiac arrhythmia in minimal time is important to prevent sudden and untimely deaths. The proposed work includes a complete framework for analyzing the Electrocardiogram (ECG) signal. The three phases of analysis include 1) the ECG signal quality enhancement through noise suppression by a dedicated filter combination; 2) the feature extraction by a devoted wavelet design and 3) a proposed hidden Markov model (HMM) for cardiac arrhythmia cla...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Abstract Atrial fibrillation is the most common cardiac arrhythmia in western society affecting more than 35 million individuals worldwide annually. It is a common postoperative complication and may also occur spontaneously during general and local anesthesia administration. Aging, diabetes mellitus, hypertension, and cardiovascular diseases including cardiomyopathies, congenital cardiac anomalies, heart failure, myocardial ischemia, pericarditis, previous cardiac surgery, vascular disease, and valvular heart disease are some correlated factors. Beyond age, increased incidence of atrial fibrillation has been corre...
Source: Annals of Cardiac Anaesthesia - Category: Anesthesiology Authors: Tags: Ann Card Anaesth Source Type: research
CONCLUSION: This study significantly contributes to defining arrhythmia competency in nurses caring for electrocardiographically monitored patients. [J Contin Educ Nurs. 2020;51(1):39-45.]. PMID: 31895469 [PubMed - in process]
Source: Journal of Continuing Education in Nursing - Category: Nursing Authors: Tags: J Contin Educ Nurs Source Type: research
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