Kenya: Sh92 Million Runs to Waste as Vaccine Expires

[Nation] Tax payers have lost Sh92 million after a new foot-and-mouth disease vaccine that had been manufactured by the veterinary agency expired following a tug-of-war between senior government officials and the corporation over a benchmarking trip.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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The use of an immune-system stimulant harvested from shark liver oil in the development of some coronavirus vaccines has animal conservationists pressing for alternatives.(Image credit: Reinhard Dirscherl/ullstein bild via Getty Images)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Publication date: Available online 8 October 2020Source: BiologicalsAuthor(s): Arnoud Akkermans, Jean-Michel Chapsal, Eliana M. Coccia, Hilde Depraetere, Jean-François Dierick, Parichat Duangkhae, Sunil Goel, Marlies Halder, Coenraad Hendriksen, Robin Levis, Koraphong Pinyosukhee, Dieter Pullirsch, Gautam Sanyal, Li Shi, Robert Sitrin, Dean Smith, Paul Stickings, Eriko Terao, Sylvie Uhlrich, Laura Viviani
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 7 October 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Piet Nuijten, Jeroen van der Loop, Mark van Rooij, Birgit Makoschey, Geert Vertenten
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
The objective of our research was to investigate the trained immunity, well-described in mouse and human, in other species of veterinary importance. For this purpose, we adapted an in vitro model of trained innate immunity in dogs. Blood enriched monocytes were stimulated with β-glucans and we confirmed that it induced an increased production of pro-inflammatory and anti-microbial compounds in response to bacterial stimuli. These results constitute the first demonstration of trained immunity in dogs and confirm its signatures in other mammalian species, with an implication of cellular mechanisms similar to those descr...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The immune system is inconveniently complicated. Aging is also inconveniently complicated. The overlap between the two is a particularly dark forest for the research community, with few well-tracked paths. The fine details of how exactly the immune system becomes dysfunctional with age, and the sizable variation in those details between individuals, will keep research teams occupied for decades to come. It seems very plausible that here, as elsewhere in the study of aging, effective rejuvenation therapies that turn back immune aging will precede a strong understanding of how they produce benefits. For example, it is...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Jennifer Doudna was sound asleep when her phone began buzzing, so she missed the first few calls. When the incessant ringing finally roused her at 3 a.m., it was a reporter who wanted her reaction to the just-awarded Nobel Prize in Chemistry. “Who won?” Doudna asked. “It was a little embarrassing,” Doudna said during a press conference held later in the day when the reporter told her she had been given the prestigious award, along with her collaborator Emmanuelle Charpentier from the Max Planck Institute. “I was really deeply asleep.” Doudna and Charpentier were jointly awarded the 2020 ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
[Monitor] District veterinary officials in the south western part of the cattle corridor have complained over insufficient vaccines against Foot and Mouth Disease (FMD), saying this may delay the vaccination exercise.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 6 October 2020Source: Veterinary MicrobiologyAuthor(s): Anna Kanci Condello, Sathya N. Kulappu Arachchige, Pollob K. Shil, Gregory J. Underwood, Amir H. Noormohammadi, Philip F. Markham, Nadeeka K. Wawegama, Glenn F. Browning
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Tardigrades are microscopic animals well-known for their stress tolerance, including the ability to survive desiccation. This survival requires cytosolic abundant heat soluble (CAHS) proteins. CAHS D protects enzymes from desiccation- and lyophilization-induced inactivation in vitro and has the potential to stabilize protein-based therapeutics, including vaccines. Here, we investigate whether purified recombinant CAHS D causes hemolysis or a toxic or immunogenic response following intraperitoneal injection in mice. CAHS D did not cause hemolysis, and all mice survived the 28-day monitoring period. The mice gained weight no...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, the earlier a zoonotic pathogen can be detected in the environment, in wildlife or in domestic animals; and the better human, animal and environmental surveillance communicate with each other to prevent an outbreak, the lower are the cumulative costs.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
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