Autologous cell replacement: a noninvasive AI approach to clinical release testing

The advent of human induced pluripotent stem cells (iPSCs) provided a means for avoiding ethical concerns associated with the use of cells isolated from human embryos. The number of labs now using iPSCs to generate photoreceptor, retinal pigmented epithelial (RPE), and more recently choroidal endothelial cells has grown exponentially. However, for autologous cell replacement to be effective, manufacturing strategies will need to change. Many tasks carried out by hand will need simplifying and automating. In this issue of the JCI, Schaub and colleagues combined quantitative brightfield microscopy and artificial intelligence (deep neural networks and traditional machine learning) to noninvasively monitor iPSC-derived graft maturation, predict donor cell identity, and evaluate graft function prior to transplantation. This approach allowed the authors to preemptively identify and remove abnormal grafts. Notably, the method is (a) transferable, (b) cost- and time effective, (c) high throughput, and (d) useful for primary product validation.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research

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Since the birth of the first child conceived via in  vitro fertilization 40 years ago, fertility treatments and assisted reproductive technology have allowed many couples to reach their reproductive goals. As of yet, no fertility options are available for men who cannot produce functional sperm, but many experimental therapies have demonstrated prom ising results in animal models. Both autologous (stem cell transplantation, de novo morphogenesis, and testicular tissue grafting) and outside-the-body (xenografting and in vitro spermatogenesis) approaches exist for restoring sperm production in infertile animals wit...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
MONDAY, Feb. 24, 2020 -- For patients with multiple myeloma (MM) treated with autologous stem cell transplantation (ASCT), long-term outcomes have improved steadily, according to a study published in the Jan. 28 issue of Blood Advances. Katherine K....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Acute Leukemia;   Myelodysplastic Syndrome Interventions:   Procedure: Hematopoietic Cell Transplantation;   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Tomotherapy;   Radiation: Total-Body Irradiation;   Radiation: Volume Modulated Arc Therapy Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Myelofibrosis, Stem Cell Transplantation, Survival Intervention:   Sponsor:   Central Hospital, Nancy, France Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplantation Infection;   Kidney Transplant; Complications;   Stem Cell Transplant Complications;   Liver Transplant; Complications;   Microbial Colonization Intervention:   Diagnostic Test: Intestinal microbiome new generation sequencing Sponsor:   Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Myelofibrosis, Stem Cell Transplantation, Survival Intervention:   Sponsor:   Central Hospital, Nancy, France Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplantation Infection;   Kidney Transplant; Complications;   Stem Cell Transplant Complications;   Liver Transplant; Complications;   Microbial Colonization Intervention:   Diagnostic Test: Intestinal microbiome new generation sequencing Sponsor:   Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Acute Leukemia;   Myelodysplastic Syndrome Interventions:   Procedure: Hematopoietic Cell Transplantation;   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Tomotherapy;   Radiation: Total-Body Irradiation;   Radiation: Volume Modulated Arc Therapy Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplantation Infection;   Kidney Transplant; Complications;   Stem Cell Transplant Complications;   Liver Transplant; Complications;   Microbial Colonization Intervention:   Diagnostic Test: Intestinal microbiome new generation sequencing Sponsor:   Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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