Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans [Biochemistry]
Feline infectious peritonitis virus (FIPV) is an alphacoronavirus that causes a nearly 100% mortality rate without effective treatment. Here we report a 3.3-Å cryoelectron microscopy (cryo-EM) structure of the serotype I FIPV spike (S) protein, which is responsible for host recognition and viral entry. Mass spectrometry provided site-specific compositions of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tzu-Jing Yang, Yen-Chen Chang, Tzu-Ping Ko, Piotr Draczkowski, Yu-Chun Chien, Yuan-Chih Chang, Kuen-Phon Wu, Kay-Hooi Khoo, Hui-Wen Chang, Shang-Te Danny Hsu Tags: PNAS Plus Source Type: research