Acute O2 sensing through HIF2{alpha}-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

We report that inactivation of Epas1 in adult mice resulted in selective abolition of glomus cell responsiveness to acute hypoxia and the hypoxic ventilatory response. Epas1 deficiency led to the decreased expression of atypical mitochondrial subunits in the carotid body, and genetic deletion of Cox4i2 mimicked the defective hypoxic responses of Epas1-null mice. These findings provide a mechanistic explanation for the acute O2 regulation of breathing, reveal an unanticipated role of HIF2α, and link acute and chronic adaptive responses to hypoxia.

Source: Signal Transduction Knowledge Environment - January 20, 2020 Category: Science Authors: Moreno-Dominguez, A., Ortega-Saenz, P., Gao, L., Colinas, O., Garcia-Flores, P., Bonilla-Henao, V., Aragones, J., Hüttemann, M., Grossman, L. I., Weissmann, N., Sommer, N., Lopez-Barneo, J. Tags: STKE Research Articles Source Type: news