Ca2+ waves coordinate purinergic receptor-evoked integrin activation and polarization

In conclusion, spatial and temporal patterns of Ca2+ increase enable fine control of αIIbβ3 activation after cellular stimulation. P2Y1-stimulated Ca2+ transients coupled to αIIbβ3 activation only in the context of P2Y12 coactivation, thereby providing an additional temporal mechanism of synergy between these Gq- and Gi-coupled GPCRs.

Source: Signal Transduction Knowledge Environment - January 20, 2020 Category: Science Authors: Bye, A. P., Gibbins, J. M., Mahaut-Smith, M. P. Tags: STKE Research Articles Source Type: news