GSE94594 NAFLD model

Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Related Links:

Authors: Canup BSB, Song H, Laroui H Abstract CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. The role of CD98 in liver disease has not thoroughly been examined and is limited reports in the literature. Among these reports, direct association for CD98 in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) have been reported. Our lab has reported that targeting CD98 in high fat diet mice reduced steatosis and inflammation in NAFLD. Other reports associate CD98 in HCC du...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Grgurevic I, Podrug K, Mikolasevic I, Kukla M, Madir A, Tsochatzis EA Abstract Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20-30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant association has been demonstrated between the inflammatory component of NAFLD, i.e., nonalcoholic steatohepatitis (NASH), and the advers...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
In conclusion, co-supplementation of PS and EPA+DHA could increase the effectiveness of treatment for hepatic steatosis. PMID: 32054543 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging evidence points towards metabolic inflammation as a key process in the fatty liver that contributes to multiorgan morbidity. Key extrahepatic comorbidities that are influenced by NAFLD are type 2 diabetes, cardiovascular disease and impaired neurocognitive function. Importantly, the presence of non-alcoholic steatohepatitis (NASH) and advanced hepatic fibrosis increase the risk for systemic comorbidity in NAFLD.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of liver disease. NAFLD develops at the interface between environmental factors and inherited predisposition. Genome-wide association studies, followed by exome-wide analyses, led to identification of genetic risk variants (e.g. PNPLA3, TM6SF2, SERPINA1) and key pathways involved in fatty liver disease pathobiology. Functional studies improved our understanding of these genetic factors and the molecular mechanisms underlying the trajectories from fat accumulation to fibrosis, cirrhosis and cancer over time.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Publication date: Available online 13 February 2020Source: Obesity Research &Clinical PracticeAuthor(s): Suna Kılınç, Tuna Demirbaş, Enver Atay, Ömer Ceran, Zeynep AtayAbstractContextEvidence suggests that the 1-h post-load plasma glucose (1-h PG) ≥155 mg/dL during an oral glucose tolerance test (OGTT) predicts development of type 2 diabetes (T2DM) and associated complications, among adults with normal glucose tolerance (NGT), but relevant data on children is scarce.ObjectivesTo investigate whether NGT children with obesity whose 1-h PG is ≥155 mg/dL have an increased carotid intima-media...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
AbstractObjectivesTo evaluate whether the liver and spleen volumetric indices, measured on portal venous phase CT images, could be used to assess liver fibrosis severity in chronic liver disease.MethodsFrom 2007 to 2017, 558 patients (mean age 48.7  ± 13.1 years; 284 men and 274 women) with chronic liver disease (n = 513) or healthy liver (n = 45) were retrospectively enrolled. The liver volume (sVolL) and spleen volume (sVolS), normalized to body surface area and liver-to-spleen volume ratio (VolL/VolS), were measured on CT images using a deep learning algorithm. The c...
Source: European Radiology - Category: Radiology Source Type: research
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease affecting approximately 25% of the global population. Although a majority of NAFLD patients will never experience liver-related symptoms it is estimated that 5 –10% will develop cirrhosis-related complications with risk of death or need for liver transplantation. NAFLD is closely associated with cardiovascular disease and components of the metabolic syndrome. However, NAFLD is not uncommon in lean individuals and may in these subjects represent a differe nt entity with separate pathophysiological mechanisms involved implying a ...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
There are no biomarkers of nonalcoholic steatohepatitis (NASH) that are ready for routine clinical use. We investigated whether an analysis of PNPLA3 and TM6SF2 genotypes (rs738409 and rs58542926) can be used to identify patients with nonalcoholic fatty liver disease (NAFLD), with and without diabetes, who also have NASH.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
This article reviews the published literature related to phytoestrogens and NAFLD as well as suggest the possible mechanisms that may underlie the association between phytoestrogens and NAFLD. It is hoped to provide basis for the treatment of NAFLD with phytoestrogen. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Review Source Type: research
More News: Genetics | Non-alcoholic Fatty Liver Diseases (NAFLD)