GSE143979 Skeletal muscle regeneration is compromised in advanced diabetic peripheral neuropathy

Contributors : Gretchen A Meyer ; Kathryn L Bohnert ; Paul Gontarz ; Bo ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDPN muscle exhibits features of degeneration with attempted regeneration. In the most severely pathological muscle samples, regeneration appears to be stymied and our data suggest that this may be partly due to intrinsic dysfunction of the satellite cell pool in addition to extrinsic structural pathology (e.g. nerve damage).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

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Publication date: Available online 21 February 2020Source: Life SciencesAuthor(s): Yu-pu Liu, Shui-jin Shao, Hai-dong GuoAbstractDiabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the patholo...
Source: Life Sciences - Category: Biology Source Type: research
We’ve all been there. You awaken in the morning and one of your hands is completely numb. It feels dead, heavy, and simply won’t work. Perhaps there’s some tingling as well. Or, you arise from a long dinner or movie and one of your legs feels that way. Then over a few minutes — maybe you shook your hands, stamped your foot — everything goes back to normal. Until the next time. The first time this happened, it might have been worrisome. Now that you know it’s temporary and happens to everyone, it may not bother you. But did you ever wonder why in the world this happens? Read on! When the ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Neurological conditions Source Type: blogs
In conclusion, 10 kHz SCS treatment resulted in significant pain relief in all the patients, decreased reliance on pain medication and improved lower limb sensory function in majority of patients. PMID: 32073352 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
AbstractBackground/aimDiabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). The Michigan Neuropathy Screening Instrument (MNSI) is a simple, brief, and useful screening tool that was designed to assess DPN. The aim of this study was to develop a Turkish version of the MNSI and assess its reliability and validity.Materials and methodsEighty-three patients with DM who were divided into two groups according the results of nerve conduction studies (NCS) as having DPN or without DPN were enrolled in this cross-sectional study. The Toronto clinical scoring system, pain detect questionnai...
Source: Diabetology International - Category: Endocrinology Source Type: research
The objectives of this paper are to review current guidelines for the pharmacological management of DPN and to discuss research rel evant to the further development of pharmacological recommendations for the treatment of diabetic neuropathy.SummaryDiabetic neuropathy is a highly prevalent, disabling condition, the management of which is associated with significant costs. Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. All current guidelines advise a personalised approach with a low ‚Äźdose start that is tailored to the maximum re...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Diabetes is one of the most common chronic diseases among persons aged
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
AbstractPainful diabetic neuropathy (PDN) is a diabetes mellitus complication. Unfortunately, the mechanisms underlying PDN are still poorly understood. Adenosine triphosphate (ATP)-gated P2X7 receptor (P2X7R) plays a pivotal role in non-diabetic neuropathic pain, but little is known about its effects on streptozotocin (STZ)-induced peripheral neuropathy. Here, we explored whether spinal cord P2X7R was correlated with the generation of mechanical allodynia (MA) in STZ-induced type 1 diabetic neuropathy in mice. MA was assessed by measuring paw withdrawal thresholds and western blotting. Immunohistochemistry was applied to ...
Source: Journal of Zhejiang University. Science. B. - Category: Universities & Medical Training Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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