Vitamin D supplementation linked to potential improvements in blood pressure in children

(University of Pittsburgh) Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose. The study did not show improvements in other markers of cardiovascular and metabolic health, a finding that indicates vitamin D supplementation alone may not be the cure-all for children at highest risk for diabetes and heart disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Merrigan SL, Park B, Ali Z, Jensen LD, Corson TW, Kennedy BN Abstract Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive administrations, may lack efficacy and are associated with poor patient compliance and tachyphylaxis. Vitamin D has de novo anti-angiogenic properties. Here, our aim was to validate the ocular anti-angiogenic activity of biologically active vitamin D, calcitriol, and selected vitamin D analogue, 2...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 22 February 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): E.F. Cornish, A. Wisentaner, D. Siassakos
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): T. Vecchiati, D. Dragà, S. Raja, G. Carioni, M. Tosi, F.D. Bassi, N. Peradze, P. Maisonneuve, P. Gnagnarella
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): D. Morlino, O. Di Vincenzo, E. Speranza, R. Sammarco, M. Marra, F. Pasanisi
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): A. Gaglio, V. Resi, E. Palmieri, V. Grancini, L. Giarratana, E. Orsi
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults. Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/ Cells are equipped with a protein disposal system in the form of the proteaso...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When I was a kid, grasshoppers were everywhere. I walked through a field every day to get to school and grasshoppers were everywhere, jumping back and forth across my path, frequently banging off my legs. At night in summer, the backyard was filled with fireflies that we’d chase and capture in jars to watch up close. And there were butterflies of many colors and varieties everywhere, flitting from flower to flower. Today, I don’t see any grasshoppers. In fact, I haven’t seen one in over 40 years. I saw one—just one—firefly this past summer in my backyard. And I can count the number of butterie...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Agribusiness bowel flora Inflammation microbiota prebiotic probiotic wheat belly Source Type: blogs
Given the void in dietary wisdom due to the ineffectiveness and blunders of “official” dietary advice, there is no shortage of books or diet programs trying to fill that void, many wildly at odds with each other—paleo, Atkins, vegan, vegetarian, high-carb, low-carb, ketogenic, etc. The U.S. Dietary Guidelines for Americans, the USDA’s MyPlate and food pyramid, and organizations such as the American Heart Association and American Diabetes Association, as well as many of the diet programs in the popular press, I believe, fail to acknowledge several fundamental principles that really need to be address...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle atkins carbs Fat gluten gluten-free grains low-carb low-fat paleo protein undoctored vegan vegetarian Weight Loss Source Type: blogs
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