Hyperglycaemia and Ischaemia Impair Wound Healing via Toll-like Receptor 4 Pathway Activation in vitro and in an Experimental Murine Model

This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in  vitro and in vivo.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research

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Publication date: Available online 19 February 2020Source: Journal of Molecular StructureAuthor(s): S. Pangajavalli, R. Ranjithkumar, S. RamaswamyAbstractIn the present study, a novel 6b', 7', 8', 9'-Tetrahydro-2H,6'H-Spiro [acenaphthylene-1,11'-chromeno [3,4-a] pyrrolizine]-2,6'(6a'H,11a'H)- dione (ACPD) single crystal was grown by the slow evaporation method. The single crystal X-ray diffraction analysis and density functional theory (DFT) calculations were carried out for the ACPD molecule. The ACPD crystallizes in the orthorhombic space group Pbca with a = 18.3519 (14) Å, b = 11.3883 (9) Å, c = 18.3545 (14)...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Azrul Abdul Kadir, Kieran Clarke, Rhys D. EvansAbstractThe ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds derived principally from fatty acids, that can be metabolised by many oxidative tissues, including heart, in carbohydrate-depleted conditions as glucose-sparing energy substrates. They also have important signalling functions, acting through G-protein coupled receptors and histone deacetylases to regulate metabolism and gene expression including ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 19 February 2020Source: Redox BiologyAuthor(s): Cláudia Figueiredo-Pereira, Daniela Dias-Pedroso, Nuno L. Soares, Helena L.A. VieiraAbstractCarbon monoxide (CO) is a gasotransmitter endogenously produced by the activity of heme oxygenase, which is a stress-response enzyme. Endogenous CO or low concentrations of exogenous CO have been described to present several cytoprotective functions: anti-apoptosis, anti-inflammatory, vasomodulation, maintenance of homeostasis, stimulation of preconditioning and modulation of cell differentiation. The present review revises and discuss how CO r...
Source: Redox Biology - Category: Biology Source Type: research
Ankush K Desai, Ugam P S Usgaonkar, Vivek S Naik, Madan Deshpande, Rajan ShuklaIndian Journal of Ophthalmology 2020 68(13):88-91 Diabetes mellitus continues to increase in epidemic proportions globally as well as in India. Poor glycemic control in long-standing diabetes mellitus eventually leads to chronic complications such as retinopathy, nephropathy, neuropathy, and cardiovascular disease. Diabetic retinopathy is emerging as an important cause of avoidable visual impairment and blindness in India across all strata of society. Much of this vision loss can be prevented by improving control of known risk factors, annual f...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in vitro and in vivo. METHODS: Fibroblasts cultured at physiological glucose concentration (5.5 mM) were exposed to glucose concentrations from 0 mM to 25 mM, with duplicates placed in a hypoxic chamber. TLR4 inhibition was assessed in the 25 mM glucose groups. Diabetes was induced in wild type (WT) and TLR4 knockout (KO) C57BL/6 mice by intraperitoneal injection of low dose streptozocin (STZ). Hindlimb ischaemia was induced by femoral artery ligation four weeks post streptozocin, a...
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in  vitro and in vivo.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Diabetes mellitus is an international epidemic. In the United States, the prevalence of diabetes has increased from estimates in 1990 when 6.5% of the population was affected and 6.2 million people had diabetes compared with the estimates in 2017 with 24.7 million people with diabetes or accounting 9.6% of the adult population. The diabetic foot syndrome manifests as a combination of diabetes-related diseases including diabetic sensory neuropathy, limited joint mobility, immunopathy, peripheral arterial disease, foot ulceration, and Charcot arthropathy. The culmination of these provides an ideal environment for unrecognize...
Source: Clinics in Podiatric Medicine and Surgery - Category: Podiatry Authors: Source Type: research
Authors: Ilonzo N, Patel M, Lantis JC Abstract Diabetes Mellitus is a serious systemic illness that has an epidemic-like increasing prevalence in the United States, as well as the rest of the world. With the increasing number of people with diabetes comes the higher incidence of diabetes-related complications. One of these known complications, diabetic foot ulcers (DFU), has an estimated lifetime incidence of 15% in diabetics. Having a DFU increases the risk of infection, amputation, and even death, which is why prompt treatment and surveillance of such ulcers is imperative. Multiple organizations and journals have...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
CONCLUSION: With the ever-increasing epidemic of DM, the number of patients with diabetic foot ulcers has also significantly risen. Early surgical management with good glycemic control and foot care with close monitoring can decrease amputations and thus foot salvage can be successfully achieved. PMID: 24155996 [PubMed]
Source: Diabetic Foot and Ankle - Category: Endocrinology Tags: Diabet Foot Ankle Source Type: research
Mainstream medicine wants you to believe the only thing you can do about diabetes is take Big Pharma’s pills or insulin shots for the rest of your life. Even if you’re not diabetic, all those carbs in your diet — cereal, pasta, potatoes, bread and sugary drinks — means your body is getting a dangerous overload of sugar. And it may be just a matter of time, before you become a statistic in America’s fastest growing health epidemic. For decades, I’ve been helping my patients not just manage their diabetes symptoms, also to reverse it for good. And I’ve also been helping them to preve...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Natural Cures diabetes guava Source Type: news
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