Methionine commits cells to differentiate into plasmablasts through epigenetic regulation of BTB and CNC homolog 2 by the methyltransferase enhancer of zeste homolog 2

ConclusionOur results showed that methionine activated signaling by controlling immunological metabolism in B cells and played an important role in the differentiation of B cells into plasmablasts through epigenome modification of BACH2 by the methyltransferase EZH2.

Source: Arthritis and Rheumatology - January 20, 2020 Category: Rheumatology Authors: Mingzeng Zhang, Shigeru Iwata, Maiko Hajime, Naoaki Ohkubo, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, He Hao, Tong Zhang, Jie Fan, Shingo Nakayamada, Kaoru Yamagata, Yoshiya Tanaka Tags: FULL LENGTH Source Type: research