“Can do, don’t do” are not the lazy ones: a longitudinal study on physical functioning in patients with COPD
Reduced physical capacity (PC) and physical activity (PA) are common in COPD patients and associated with poor outcome. However, they represent different aspects of physical functioning and interventions do no...
ConclusionsThese findings suggest that glycopyrronium, formoterol, and a combination of glycopyrronium, formoterol, and budesonide inhibit HCoV-229E replication partly by inhibiting receptor expression and/or endosomal function and that these drugs modulate infection-induced inflammation in the airway.
Authors: Pelaia C, Vatrella A, Sciacqua A, Terracciano R, Pelaia G Abstract Introduction: The p38 serine-threonine kinases are members of the large family of mitogen-activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms (α, β, γ, δ), among which p38α and p38β are mainly involved in inflammatory disorders. Indeed, by activating key transcription factors and by inducing the expression of several cytokines and chemokines, p38α plays a central role in the pathobiology of chronic obstructive pulmonary disease (COPD).Areas covered: This concise r...
Authors: Crisafulli E, Manco A, Torres A Abstract Introduction: In a subset of chronic obstructive pulmonary disease (COPD)patients the course of the disease is complicated by a severe acute exacerbations (AECOPD) that may require hospitalization, at which time negative outcomes may occur up to 30 days after discharge. Several predictors of negative outcomes have been documented.Areas covered: We considered five negative outcomes related to patients hospitalized with AECOPD: treatment failure, non-invasive mechanical ventilation (NIMV) failure, prolonged length of hospital stay (LHS), short-term mortality (≤ 90 ...
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): F. Monfrecola, A. Di Gregorio, F. de Blasio, P. Alicante, G. Miracco Berlingieri, F. de Blasio, L. Scalfi
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): F. de Blasio, L. Garello, M. Comune, A. Oliva, C. Bucca
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): P. Alicante, F. Monfrecola, A. Di Gregorio, F. de Blasio, B. Bellofiore, F. de Blasio, L. Scalfi
ConclusionsThis large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies.
Introduction: Body composition and physical fitness (PF) are major components of nutritional status which may be evaluated in the clinical setting using bioelectrical impedance analysis (BIA) and a number of different specific tests, respectively. Chronic obstructive pulmonary disease (COPD) is a chronic disease that is usually progressive and frequently associated with poor nutritional status.
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a chronic and progressive respiratory disease, commonly associated with alterations of nutritional status. Among these, low Vitamin D levels are frequent and related to disease severity, risk of exacerbations and annual hospitalizations and general health status of individual patients.
Introduction: The evaluation of physical fitness (PF) has been gaining importance over the last years in the assessment of nutritional status in patients with chronic obstructive pulmonary disease (COPD).