The impact of COPD on polyneuropathy: results from the German COPD cohort COSYCONET

Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction be...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research

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Motives for cannabis use are hardly generated by users themselves nor are they validated for German users. We therefore aimed to replicate the motive structure of established questionnaires (e.g., MMM and CMMQ) in young German adults. In a cross-sectional ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conclusion: The results of our unsupervised classification algorithm based on three variables of laboratory tests correlated well with the neurologists' diagnoses. PMID: 32076460 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
ConclusionsPhysiological fatigue seems to have no impact on shooting accuracy, but rather affects shooting times in expert biathletes. Furthermore, the duration of the final fixation does not seem to moderate shooting accuracy in elite biathletes.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
ConclusionsThese findings suggest that glycopyrronium, formoterol, and a combination of glycopyrronium, formoterol, and budesonide inhibit HCoV-229E replication partly by inhibiting receptor expression and/or endosomal function and that these drugs modulate infection-induced inflammation in the airway.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Authors: Pelaia C, Vatrella A, Sciacqua A, Terracciano R, Pelaia G Abstract Introduction: The p38 serine-threonine kinases are members of the large family of mitogen-activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms (α, β, γ, δ), among which p38α and p38β are mainly involved in inflammatory disorders. Indeed, by activating key transcription factors and by inducing the expression of several cytokines and chemokines, p38α plays a central role in the pathobiology of chronic obstructive pulmonary disease (COPD).Areas covered: This concise r...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Crisafulli E, Manco A, Torres A Abstract Introduction: In a subset of chronic obstructive pulmonary disease (COPD)patients the course of the disease is complicated by a severe acute exacerbations (AECOPD) that may require hospitalization, at which time negative outcomes may occur up to 30 days after discharge. Several predictors of negative outcomes have been documented.Areas covered: We considered five negative outcomes related to patients hospitalized with AECOPD: treatment failure, non-invasive mechanical ventilation (NIMV) failure, prolonged length of hospital stay (LHS), short-term mortality (≤ 90 ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 22 February 2020Source: Aggression and Violent BehaviorAuthor(s): Friederike Sommer, Vincenz Leuschner, Nora Fiedler, Eric Madfis, Herbert ScheithauerAbstractMost research on severe targeted school violence (STSV) - defined as planned offenses committed by former or current students intending to kill one or more persons associated with their school - is related to risk factor approaches or theoretically informed models and thus lacks an empirical explanation of underlying mechanisms and the dynamic of contextual variables that caused or accompanied perpetrators' negative development towar...
Source: Aggression and Violent Behavior - Category: Psychiatry & Psychology Source Type: research
Conclusion: 16 of 19 studies treated by CHM granules only showed positive result in 7 diseases and negative result in 1 disease. 17 of 21 studies treated by combination therapy against conventional therapy showed positive result in 6 diseases and negative result in 3 diseases. However, both the absolute and relative effectiveness of CHM formula granules compared with placebo need to be considered clinically. PMID: 31110552 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study provides class IV evidence that elevated sVEGF levels accurately identifies patients with POEMS syndrome.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Diagnostic test assessment, Hematologic, Peripheral neuropathy Article Source Type: research
Chronic pulmonary aspergillosis (CPA) complicates conditions including tuberculosis, chronic obstructive pulmonary disease and sarcoidosis, and is associated with high morbidity and mortality. Surgical cure should be considered where feasible; however, many patients are unsuitable for surgery due to extensive disease or poor respiratory function. Azoles are the only oral drug with anti-Aspergillus activity and itraconazole and voriconazole are considered as first-line drugs. A randomized controlled trial demonstrated improvement or stability in three-quarters of patients given 6 months of itraconazole, but a quarter relaps...
Source: Respiration - Category: Respiratory Medicine Source Type: research
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