Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Residual Burn Wound

Condition:   the Safety and Effectiveness of Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Residual Burn Wound Interventions:   Biological: epidermal growth factor;   Biological: mesenchymal stem cell conditioned medium-derived pleiotropic factor Sponsor:   Chinese PLA General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Injuries of the largest anatomical organ, the skin, resulting from trauma, burns, or inflammatory disorders can lead to devastating health effects. Modern approaches to re-establishing critical barrier functions have evolved from simple biomaterial dressings to sophisticated skin grafts. A report by Magne et  al. (2019) describes the exciting use of IL-1β–pretreated gingival mesenchymal stem cells to enhance skin graft functions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
Abstract BACKGROUND/AIMS: To evaluate long-term visual outcomes of Boston type I keratoprosthesis (KPro) surgery and identify risk factors for visual failure. METHODS: Single surgeon retrospective cohort study including 85 eyes of 74 patients who underwent KPro implantation to treat severe ocular surface disease, including limbal stem cell deficiency, postinfectious keratitis, aniridia and chemical burns. Procedures were performed at the Centre hospitalier de l'Université de Montréal from October 2008 to May 2012. All patients with at least 5 years of follow-up were included in the analysis, inc...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Sudden death could be the first symptom of patients with arrhythmogenic cardiomyopathy (AC), a disease for which clinical indicators predicting adverse progression remain lacking. Recent findings suggest that metabolic dysregulation is present in AC. We performed this study to identify metabolic indicators that predicted major adverse cardiac events (MACEs) in patients with AC and their relatives. Comparing explanted hearts from patients with AC and healthy donors, we identified deregulated metabolic pathways using quantitative proteomics. Right ventricles (RVs) from patients with AC displayed elevated ketone metabolic enz...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Researchers at the University of Toronto have developed a handheld 3D printer that can deposit a stem cell-loaded bioink onto wounds, such as burns, to promote tissue healing. The device acts like a paint roller, and a clinician could use it to depos...
Source: Medgadget - Category: Medical Devices Authors: Tags: News Plastic Surgery Source Type: blogs
Regeneration is the natural process of replacing or restoring cells that have been lost or damaged due to injury or disease. A few animals can regrow entire organs or other body parts, but most have limited abilities to regenerate. Scientists in the field of regenerative medicine study how some animals are able to rebuild lost body parts. By better understanding these processes and learning how to control them, researchers hope to develop new methods to treat injuries and diseases in people. Take this quiz to test what you know about regeneration and regenerative medicine. Then check out our Regeneration fact sheet a...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Genes Cellular Processes Regeneration Source Type: blogs
Abstract The deteriorating effects of heat stress abrogate the therapeutic implications of human Wharton's jelly derived mesenchymal stem cells (hWJMSCs) transplanted in burn wounds. Topically applied green tea extract comprising epigallocatechin-3-gallate (EGCG) is known to repair burn wounds. Here, we investigated the protective role of EGCG priming of hWJMSCs against heat-induced stress in vitro along with the involved underlying mechanism. EGCG ameliorated heat-induced injuries as demonstrated by significantly improved cell morphology, viability, triggered cell migration and enhanced expression of heat shock p...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Condition:   the Safety and Effectiveness of Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Residual Burn Wound Interventions:   Biological: epidermal growth factor;   Biological: mesenchymal stem cell conditioned medium-derived pleiotropic factor Sponsor:   Chinese PLA General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to i...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
The objective of this article is to observe the function of the miR-21 expressed in the adipose AD-exos and the effect on migration and proliferation of the HaCaT cells. MATERIALS AND METHODS: The full layer dermal wound of BALb/c mouse was used to observe the vitro effect of the AD-exos and detect the expression of miR-21.The co-culture systems were established by transwell plates for observing the migration, proliferation, apoptosis rate, and detecting the RNA, and protein expression in different treated groups. miR-21 plasmid was used to over-express miR-21 by transfection of HaCaT cells. GW4869 was used to inhibit...
Source: Archives of Biochemistry and Biophysics - Category: Biochemistry Authors: Tags: Arch Biochem Biophys Source Type: research
Killer immunoglobulin-like receptor (KIR) genes participate in the regulation of natural killer (NK) cell function, and mismatch between transplant donor and recipient improves clinical outcomes in some transplantation settings [1-6]. Lower than expected rates of relapse, graft failure, and graft-versus-host disease (GVHD) occur in KIR-incompatible, T cell-depleted, HLA-mismatched related donor hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) [5]. Similarly, Hsu et al [7] reported superior overall survival (OS) and disease-free survival (DFS) for recipients of KIR-incompatible HCST compar...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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