Spine Disorders and Regenerative Rehabilitation

AbstractPurpose of ReviewThe purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders.Recent FindingsImmunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis.SummaryWhile current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research