Pre-analytical variables for the genomic assessment of the cellular and acellular fractions of the liquid biopsy in a cohort of breast cancer patients

The liquid biopsy allows assessment of multiple analytes providing temporal information with potential for improving our understanding of cancer evolution and clinical management of patients. While liquid biopsies are intensely investigated for prediction and response monitoring, pre-analytic variables are of primary concern for clinical implementation, including categories of collection methodology and sample storage. Here we utilize an integrated high-definition single cell assay (HD-SCA) workflow for morphometric and genomic analysis of the liquid biopsy to characterize the effects of pre-analytical variation and reproducibility of data from a breast cancer cohort.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular Article Source Type: research