Forced conceptual thought induced by electrical stimulation of the left prefrontal gyrus involves widespread neural networks

ConclusionsWe illustrate the neural networks involved in conceptual thought through a unique patient population and argue that PFC supports this function through activation of a widespread network.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Authors: Cirnigliaro G, Di Bernardo I, Caricasole V, Piccoli E, Scaramelli B, Pomati S, Villa C, Pantoni L, Dell'Osso B Abstract Introduction: Transient localized lesions of the splenium of the corpus callosum (SCC) have been described in various clinical conditions, some of them being attributed to the withdrawal of psychotropic drugs. The pathophysiology of the lesion likely reflects cytotoxic edema and reversible demyelination.Areas covered: The present article aimed at reviewing cases of transient SCC lesion exclusively related to changes in pharmacological treatment. It also reports the original case of a psyc...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
ConclusionThe present study demonstrated that closure of the widely opened frontal sinus using DuraGen inserted between the skull and the pericranium flap is an effective and promising method for the frontal sinus isolation.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusions: Thirty-two AE patients were recruited over 18 months. Twenty-one viral controls, 10 NI controls, and five other autoimmune neurological disease controls (AOND) were also included in the analysis. Our study found that conventional markers: presence of CSF monocytosis, oligoclonal bands, anti-neuronal immunofluorescence, and magnetic resonance imaging (MRI) changes could be suggestive of AE, but these investigations were neither sensitive nor specific. Promising novel makers of autoimmune encephalitis were the CSF cytokines IL-21 and IP10 which may provide better delineation between viral infections and autoimmu...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: The literature describes abnormalities in cranial magnetic resonance imaging in 10-20% of diagnosed cases of PS in which a scan is performed, although the diagnosis of PS is not always changed (matching lesions). Both cases exemplify the importance of reaching a correct diagnosis through a detailed study that must include neuroimaging, since, in some patients, causal brain injuries will be detected and as a result the diagnosis, treatment and evolution will be significantly different. PMID: 32043535 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
CONCLUSION: MWA may be associated with reversible lesions of the corpus callosum. PMID: 32048282 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
This study demonstrates that the presence of abnormal patterns in resting state neural network connectivity may underlie the working memory disruptions that frequently characterize the neurocognitive pr ofile of youth with epilepsy.
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Publication date: Available online 6 February 2020Source: Academic RadiologyAuthor(s): Liu Songjiang, Zhang Tijiang, Liu Heng, Zhang Wenjing, Tao Bo, Song Ganjun, Tian Maoqiang, Lui SuRationale and ObjectiveEpilepsy is a common pediatric disease that often leads to cognitive and intellectual impairments. Here, we explore the reorganized functional networks in children and adolescents with focal epilepsy (CAFE) and analyze the relationship between network reorganization and intellectual deficits to reveal the underlying link between them.Materials and MethodsFifty-four CAFE (6–16 years old; right-handed) and 42 well-m...
Source: Academic Radiology - Category: Radiology Source Type: research
An 11-year-old boy without personal or family history of epilepsy had frequent nighttime awakenings. A polysomnogram revealed obstructive and central sleep apneas. Tonsillectomy was performed for obstructive sleep apneas. Due to the presence of central sleep apneas, Magnetic Resonance Imaging (MRI) of the brain was completed. Interpretation of the test identified incidental subcortical band heterotopias (SBH). Chromosomal microarray revealed a 46 XY male. Whole exome sequencing demonstrated mosaicism for a pathologic de novo missense mutation (Arg186His) in exon 3 of the doublecortin (DCX) gene with low hemizygosity (13.46%).
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Visual Diagnosis Source Type: research
CONCLUSION: These findings reveal an increase in metabolism in the motor cortex during general cortical dysfunction in the frontal and occipital cortices in SHM. Key words: FDG-PET, hemiplegic migraine, migraine, positron emission tomography, SISCOM. PMID: 32002978 [PubMed - in process]
Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Abstract Neurosurgery has been at the forefront of a paradigm shift from a localizationist perspective to a network-based approach to brain mapping. Over the last 2 decades, we have seen dramatic improvements in the way we can image the human brain and noninvasively estimate the location of critical functional networks. In certain patients with brain tumors and epilepsy, intraoperative electrical stimulation has revealed direct links between these networks and their function. The focus of these techniques has rightfully been identification and preservation of so-called "eloquent" brain functions (i.e., m...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
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