Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors

Conclusion The N-terminus domain constitutes an important structural determinant for the functional oligomerization of RyR2. Our findings are consistent with defective N-terminus self-association as a molecular mechanism underlying RyR2 channel deregulation in inherited arrhythmogenic cardiac disease. Significantly, the therapeutic action of dantrolene may occur via the restoration of normal RyR2 N-terminal intersubunit interactions.

http://cardiovascres.oxfordjournals.org/cgi/content/short/105/1/118?rss=1

Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Seidel, M., Lowri Thomas, N., Williams, A. J., Anthony Lai, F., Zissimopoulos, S. Tags: Ion channels and arrhythmias Source Type: research