Identification of PI3K regulatory subunit p55{gamma} as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation

Conclusion
These findings mark p55 as a novel upstream regulator of the p53-p21 signalling pathway that negatively regulates VSMC proliferation, suggesting that malfunction of p55 may trigger vascular proliferative disorders.

Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Li, G., Xie, N., Yao, Y., Zhang, Y., Guo, J., Feng, Y., Lv, F., Xiao, R.-P., Cao, C.-M. Tags: Vascular biology Source Type: research