Pharmacological inhibition of TGF{beta} receptor improves Nkx2.5 cardiomyoblast-mediated regeneration

Conclusion Pharmacological inhibition of TGFβ signalling improved cardiac function in injured mice and promoted the expansion and cardiomyogenic differentiation of Nkx2.5+ cardiomyoblasts. Direct modulation of resident cardiomyoblasts in vivo may be a promising strategy to enhance therapeutic cardiac regeneration.

http://cardiovascres.oxfordjournals.org/cgi/content/short/105/1/44?rss=1

Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Chen, W.-P., Liu, Y.-H., Ho, Y.-J., Wu, S. M. Tags: Cardiac biology and remodelling Source Type: research