Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts

Conclusions
Nuclear transport changes related to increased export and decreased import are an early event in hypertrophic development. Hypertrophy can be prevented, or even reversed, by targeting import/export, which may open new therapeutic opportunities.

Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Chahine, M. N., Mioulane, M., Sikkel, M. B., O'Gara, P., Dos Remedios, C. G., Pierce, G. N., Lyon, A. R., Foldes, G., Harding, S. E. Tags: Cardiac biology and remodelling Source Type: research