Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (KIR) Genes: A Meta-Analysis.

Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (KIR) Genes: A Meta-Analysis. Immunol Invest. 2020 Jan 20;:1-12 Authors: Enciso-Vargas M, Alvarado-Ruíz L, Suárez-Villanueva AS, Macías-Barragán J, Montoya-Buelna M, Oceguera-Contreras E, Alvarado-Navarro A, Graciano-Machuca O Abstract Background: Psoriatic Arthritis (PsA) is a seronegative spondyloarthropathy frequently associated with psoriasis. Studies have shown different members of the KIR (Killer Immunoglobulin-like Receptor) gene family may act as potential susceptibility factors; however, data have been inconsistent or with a reduced sample size. Therefore, the objective of this investigation was to determine associations between KIR genes and PsA susceptibility a meta-analysis approach.Methods: We performed a systemic search on PubMed, Scopus, and Web of Science to identify association studies linking KIR genes with PsA susceptibility. The search cut-off was May 2019. Odds Ratio (OR), 95% Confidence Intervals (95% CI), and forest plots were obtained for each KIR gene. Publication bias was evaluated by Begg and Egger linear regression tests.Results: Five articles were included in this meta-analysis. The KIR2DL2, 2DS1, 2DS2, and 2DS3 genes were positively associated with susceptibility to PsA (OR = 1.269, p = .003; OR = 1.392, p
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

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Conclusions: These data suggest biomarker analysis can reflect disease activity across disease domains in PsA. Certain domains would likely benefit from evaluation of additional biomarkers. PMID: 32067517 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
(JAMA Network) This observational study was a systematic review and meta-analysis that included 112 studies and examined the association between risk of cancer in patients with psoriasis or psoriatic arthritis, including the risk of specific cancers.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This systematic review and meta-analysis evaluates the association between cancer and psoriasis or psoriatic arthritis.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
We report the results of a prospective study evaluating the adalimumab biosimilar Exemptia (ZRC 3197; Zydus Cadi la, Gujarat, India) in PsA with concomitant psoriasis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Letter Source Type: research
AbstractPsoriatic arthritis and gout are frequently encountered conditions sharing a number of common risk factors, which render their independent study difficult. Epidemiological studies have demonstrated a strong link between these diseases, suggesting the presence of underlying, intertwined pathophysiological mechanisms that currently remain unknown. Indeed, sodium urate crystals could play a pathogenic role in psoriasis and psoriatic arthritis. In daily practice, the distinction between psoriatic arthritis associated with hyperuricemia and a gouty arthropathy with psoriasis is complex. Several common pathogenic feature...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
CONCLUSION: The accuracy of case definition algorithms for psoriasis and PsA varies widely. However, selected algorithms produced population prevalence estimates which were within the expected ranges, suggesting that they may be useful for future research purposes. PMID: 32062600 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Authors: Perez-Chada LM, Balak D, Cohen JM, Ogdie A, Merola JF, Gottlieb AB Abstract Introduction: The International Dermatology Outcome Measures (IDEOM) identified 'Psoriatic Arthritis (PsA) Symptoms' as a core domain to be measured in psoriasis clinical trials. This domain includes the measurement of pain, patient global and physical function. Herein, we evaluated the quality (i.e. measurement properties) of five candidate 'PsA Symptoms' measures: Patient Global Assessment (PGA) for Joints, PGA for PsA, the Routine Assessment Patient Index 3 (RAPID3), the PsA Impact of Disease 9 (PsAID9) and PsAID12.Areas covered...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
Abstract BACKGROUND: We previously found that serum levels of C-X-C motif chemokine 10 (CXCL10) decreased after PsA onset. OBJECTIVE: We measured CXCL10 levels over time in psoriasis patients who developed PsA to determine whether the drop in CXCL10 was specific to these patients and further assess its association with PsA development. METHODS: Prospectively followed psoriasis patients without arthritis (psoriasis cutaneous [PsC]) were assessed yearly by rheumatologists for the presence of PsA. PsC patients who developed PsA (converters) were matched to those that did not develop PsA (non-converters) bas...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Review Source Type: research
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