Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation

ConclusionOur work demonstrated that WMW can prevent intestinal fibrosis and the mechanisms involved may be related to the inhibition of colon fibroblasts activation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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This study was a retrospective, non-inferiority study conducted within a US integrated healthcare system and included adult patients with a confirmed diagnosis of Crohn ’s disease or ulcerative colitis. A 1:1 propensity score matching was utilized to match patients who switched to infliximab-dyyb during the period April 2016–March 2018 to patients who remained on RP infliximab. The non-inferiority margin was set at + 10% of the upper limit. The primary outcome was a composite measure of disease worsening requiring acute care after the index date of switching to infliximab-dyyb or continuing RP infliximab. Disea...
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
Authors: Meng J, Huang S, Sun C, Zhang ZW, Mao R, Yang YH, Feng ST, Li ZP, Li X Abstract OBJECTIVE: To establish a novel standardized magnetization transfer ratio (MTR) parameter which considers the element of the normal bowel wall and to compare the efficacy of the MTR, normalized MTR, and standardized MTR in evaluating intestinal fibrosis in Crohn's disease (CD). MATERIALS AND METHODS: Abdominal magnetization transfer imaging from 20 consecutive CD patients were analyzed before performing elective operations. MTR parameters were calculated by delineating regions of interest in specified segments on MTR maps. ...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
Condition:   Crohn Disease Intervention:   Sponsors:   Weizmann Institute of Science;   The Leona M. and Harry B. Helmsley Charitable Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract CT enterography and magnetic resonance (MR) enterography are widely used imaging modalities used to examine the small bowel. These radiologic tests are distinguished from routine abdominopelvic CT and MRI by the oral ingestion of a large amount of neutral contrast to distend the small bowel before scanning. For achievement of high quality, diagnostic images and proper technique are required. Conducted protocols still vary in patient preparation, enteric contrast, and CT and MRI acquisition sequences, resulting in heterogeneous diagnostic accuracy. The purpose of this article is to review the processes and...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
ConclusionUsing the obstruction protocol in patients with bowel obstruction reduced emergency surgery and postoperative morbidity and mortality in this pilot study. This protocol seems to be a viable and efficient alternative to emergency surgery.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusions: VDZ is associated with mucosal healing in pediatric IBD. Anti-TNF exposure significantly impacted endoscopic remission, but not histologic remission in children on VDZ.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Objective: Infliximab (IFX) is a frequent therapeutic option for Crohn disease (CD) patients. Early detection of responders to IFX is critical for the management of CD in order to avoid long-term exposure to the drug without benefit. This retrospective study aimed at analysing which early parameters recorded during the induction period are able to predict response to IFX during the maintenance period in pediatric CD. Patients and Methods: Medical records of all CD patients ages from 2 to 18 years who received IFX at a tertiary IBD center were retrospectively analyzed. Children were classified in 3 groups according to ...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Conclusions: The present study explores the prevalence and presentation of perfectionism in a sample of adolescents with IBD. Results suggest dimensions of perfectionism are differentially associated with psychosocial and disease management outcomes, suggesting further evidence of the relationship between perfectionism, maladaptive coping, and subsequent influences on health outcomes in the context of pediatric chronic illness.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Authors: Yue Ying C, Jun S, Yu Fan W, Hua RZ Abstract Introduction: Anemia is a common extraintestinal complication of Crohn's disease (CD) mainly caused by iron deficiency and, affects the quality of life of CD patients. In recent years, the etiology and pathology of iron-deficiency anemia (IDA) and anemia of chronic diseases have been elucidated. However, common biochemical parameters of iron status for the assessment of patients with anemia and CD are insufficient. Thus, novel iron indices are required for accurate assessment in CD patients with IDA. Oral iron supplementation as IDA treatment is common and assoc...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Hello all! This is my second post on SDN. I am a biomedical engineering pre-med who is currently in my sophomore year. I am currently in the worst semester I have ever taken in my college career. It was going well at first, but then, and I know it's really stupid, but I heard that the coronavirus was in my University, and since I have a low immune system due to Crohn's and Remicade, I began to skip a lot of classes and now I'm playing catchup. Most likely I will get a a low GPA this... Deathly worried about my future as a pre-med!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
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