Metabolic disturbance in Korean red ginseng-induced “Shanghuo” (excessive heat)

ConclusionsOverconsumption of KRG could induce “Shanghuo”, which has a close relationship with an accelerated TCA cycle and the increased AMPK activity.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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In this study, we examined the effect of chemical structure, octanol/water partition coefficient (log P), and Henry’s law constant (Hc) on the encapsulation and the release of monoterpenes (eucalyptol, pulegone, terpineol, and thymol) and phenylpropenes (estragole and isoeugenol) from DCLs. Hydroxypropyl-β-cyclodextrin/EO component (HP-β-CD/EO component) inclusion complexes were prepared in aqueous solution and loaded into liposomes by the ethanol injection method. The phospholipid:cholesterol:EO component molar ratio determined for DCL structures was affected by characteristics of EO components. The presen...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 15 February 2020Source: Clinica Chimica ActaAuthor(s): Yao-Chang Liu, Jen-Pi Tsai, Li-Hsuan Wang, Ming-Che Lee, Bang-Gee HsuAbstractBackgroundFibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients.MethodsThe fasting blood samples of RT recipients (n=66) were collected and analyzed.ResultsA total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a hig...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 14 February 2020Source: American Heart JournalAuthor(s): Bao-Oanh Nguyen, Michiel Rienstra, Anne H. Hobbelt, Jan G.P. Tijssen, Marcelle D. Smit, Robert G. Tieleman, Bastiaan Geelhoed, Dirk J. Van Veldhuisen, Harry J.G.M. Crijns, Isabelle C. Van Gelder, RACE 3 InvestigatorsAbstractAtrial fibrillation (AF) is a progressive disease, and maintenance of sinus rhythm is cumbersome. In this analysis of the Routine versus Aggressive risk factor driven upstream rhythm Control for prevention of Early atrial fibrillation in heart failure (RACE 3) trial we aimed to determine whether optimal treatment...
Source: American Heart Journal - Category: Cardiology Source Type: research
The objective of this study was designed to evaluate the association between physiological responses, hormonal, hematological and serum biochemical values features aiming to propose an adaptability index (AI) for dairy cows in tropical conditions. Thirty adult dairy cows were used, including 15 Sindi and 15 Girolando breeds with mean weight of 338.52 ± 42.79 kg and 487.54 ± 60.67 kg, respectively. These data included rectal temperature (RT), respiratory rate (RR), both were measured twice a once a month for twelve months. For the serum of blood sample, the levels of glucose (GLU), cholesterol (CHO...
Source: Journal of Thermal Biology - Category: Biology Source Type: research
Publication date: Available online 14 February 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Hong Chen, Qianru Zhang, Ruimin Chen, Xin Yuan, Xiangquan Lin, Xiaohong Yang, Ying ZhangAbstractCongenital adrenal hyperplasia (CAH) encompasses a group of autosomal recessive diseases characterized by enzymatic defects in steroid synthesis. Lipoid congenital adrenal hyperplasia (LCAH) is the most severe form of CAH, insofar as the initial step of steroid synthesis is impaired. Variants in the steroid acute regulatory (STAR) gene are responsible for LCAH. To describe the clinical and genetic charac...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
The objective of the study is to determine whether practice facilitation is effective in increasing the proportion of patients meeting the Million Hearts ABCS outcomes: (A) aspirin when indicated, (B) blood pressure control, (C) cholesterol management, and (S) smoking screening and cessation intervention.DesignThe study used a stepped-wedge cluster RCT design with 4 intervention waves. Data were extracted for 13 quarters between January 1, 2015 and March 31, 2018, which encompassed the control, intervention, and follow-up periods for all waves, and analyzed in 2019.Setting/participantsA total of 257 small independent prima...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Ozbay S, Ulupınar S, Şebin E, Altınkaynak K Abstract The aim of this study is to investigate the acute and chronic effects of aerobic training performed indoors and outdoors on irisin, adropin, and cholesterol levels in winter. Thirty-two healthy males participated in this study. Participants were divided into two groups: outdoor group (n = 16) and indoor group (n = 16). They then performed 40-min aerobic running exercises 4 days/week for 18 weeks. The outdoor group trained at -5°C-5°C environmental temperature, while the indoor group trained at 21°C-25°C. Blood samples were collected be...
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research
This study aimed at investigating the possible protective effect of Hypoxis hemerocallidea (HH) against metabolic and hepatic histomorphology of diabetic rats under HAART. Material and methods: Sixty-two adult male Sprague-Dawley rats were divided into a normoglycemic group A (n = 6) and 7 diabetic (110 mg/kg nicotinamide + 45 mg/kg streptozotocin) groups (B-H) (n = 8) and treated according to protocols. Concomitant treatment with adjuvant HH and HAART resulted in the least %body weight gain as the liver weight decreased in all treated animals. Results: Significant changes in serum lipids were aggravated by treatme...
Source: Archives of Medical Science - Category: Biomedical Science Tags: Arch Med Sci Source Type: research
Publication date: Available online 15 February 2020Source: Canadian Journal of CardiologyAuthor(s): Pauline Mury, Jocelyn Dupuis, Eric Thorin
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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