Examination of pathological features of the right atrioventricular groove in hearts with Ebstein ’s anomaly, and correlation with arrhythmias

Catheter ablation of accessory pathways (AP) in Ebstein ’s anomaly (EA) has a higher recurrence rate than in normal hearts. Anatomic features could account for suboptimal ablation outcomes.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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This was sent by a reader:" I would really appreciate your thoughts on this ekg progression. 71 yo F, only risk factor hyperlipidemia, has isolated chest discomfort, non-exertional and non-radiating. "Sinus rhythm with one PVC.What do you think?Smith response:This ECG has symmetric (hyperacute) T-waves in V2-V4.  It is diagnostic of LAD occlusion.If you're uncertain, use theformula: https://hqmeded-ecg.blogspot.com/2017/11/12-cases-of-use-of-3-and-4-variable.htmlI applied it here after measuring a QTc of 440 ms.The value comes to 19.73 (greater than 18.2 is quite good for Diagnosis of LAD occlusion...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Conclusions: Esophageal wire traction shortens the clearance time for the left recurrent laryngeal nerve lymph nodes, reduces thoracic bleeding, and improves the quality of left recurrent laryngeal nerve lymph node dissection in three-hole thoracoscopic esophagectomy. PMID: 32091290 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
New Brunswick, NJ, February 25, 2020 — Johnson &Johnson (NYSE: JNJ) today announced that the Janssen Pharmaceutical Companies of Johnson &Johnson, in collaboration with Apple, opened enrollment for the Heartline™ Study. The study is designed to explore if the Heartline™ Study app on iPhone and heart health features on Apple Watch can improve health outcomes, including reducing the risk of stroke, with earlier detection of atrial fibrillation (AFib). AFib, a common form of irregular heart rhythm, is a leading cause of stroke in the U.S. To enroll in the Heartline™ Study, individuals must be a...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
The low cost of thiazolidinediones makes them a potentially valuable therapeutic option for the  > 300 million economically disadvantaged persons worldwide with type 2 diabetes mellitus. Differential selectivit...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
Regular drinkers with atrial fibrillation who drastically reduced their alcohol consumption had fewer arrhythmia recurrences, a multicenter Australian trial published in the New England Journal of Medicine found.
Source: JAMA - Category: General Medicine Source Type: research
by Jieyun Bai, Andy Lo, Patrick A. Gladding, Martin K. Stiles, Vadim V. Fedorov, Jichao Zhao Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause of stroke and morbidity. Recent genome-wide association studies have shown that paired-like homeodomain transcription factor 2 (Pitx2) to be strongly associated with AF. However, the mechanisms underlying Pitx2 modulated arrhythmogenesis and variable effectiveness of antiarrhythmic drugs (AADs) in patients in the presence or absence of impaired Pitx2 expression remain unclear. We have developed multi-scale computer models, ranging from a ...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
The Preventive Ablation of Ventricular Tachycardia in Patients with Myocardial Infarction (BERLIN VT) trial investigators (Willems et  al; Circulation 2020;Epub ahead of print, PMID 32000514) sought to assess the effect of timing of ablation for ventricular tachycardia (VT) in patients with previous myocardial infarction (MI). In this randomized trial conducted at 26 European centers, patients with history of previous MI and left ventricular ejection fraction 30%–50% who presented with life-threatening ventricular arrhythmias necessitating implantable cardioverter–defibrillator (ICD) implantation were rand...
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP News Source Type: research
Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular level to drive action potentials and to maintain action potential propagation and electrical homogeneity at the tissue level. Any imbalance in Ca2+ homeostasis of a cardiac myocyte can lead to electrical disturbances. This review aims to discuss cardiac physiology and pathophysiology from the elementary membrane...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Lung cancer is the most common cancer worldwide, accounting for approximately 17% and 9% of all cancers in men and women, respectively, and more than 1.6 million cancer-related deaths every year [1]. Patients with non-metastatic disease are eligible for curative treatment, which can include various combinations of surgery, chemotherapy and radiotherapy [2 –4]. The risk of experiencing major morbidity from surgery ranges from 10%-30% and most common symptomatic complications include arrhythmias, pneumonia and pulmonary embolism [5].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Response by Lüker et al to Letter Regarding Article, "Internal Versus External Electrical Cardioversion of Atrial Arrhythmia in Patients With Implantable Cardioverter-Defibrillator: A Randomized Clinical Trial". Circulation. 2020 Feb 25;141(8):e95-e96 Authors: Lüker J, Kuhr K, Sultan A, Nölker G, Omran H, Willems S, Andrié R, Schrickel JW, Winter S, Vollmann D, Tilz RR, Jobs A, Heeger CH, Metzner A, Meyer S, Mischke K, Napp A, Fahrig A, Steinhauser S, Brachmann J, Baldus S, Mahajan R, Sanders P, Steven D PMID: 32091927 [PubMed - as supplied by publisher]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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