Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis

Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis.

Source: Atherosclerosis - January 20, 2020 Category: Cardiology Authors: Xiangyuan Pu, Kenneth Chan, Wei Yang, Qingzhong Xiao, Li Zhang, Andrew D. Moore, Chuanju Liu, Tom R. Webb, Mark J. Caulfield, Nilesh J. Samani, Jianhua Zhu, Shu Ye Source Type: research