Drug treatment of chronic subdural hematoma.

Drug treatment of chronic subdural hematoma. Expert Opin Pharmacother. 2020 Jan 20;:1-10 Authors: Huang J, Gao C, Dong J, Zhang J, Jiang R Abstract Introduction: Chronic subdural hematoma (CSDH) is a common neurosurgical disease, whose incidence has been steadily increasing with our aging population. While not common, CSDH can also occur in children. CSDH is often associated with traumatic head injury, but its underlying mechanism remains poorly understood. The first line treatment for CSDH is surgery. However, surgery is contraindicated in some patients and has a high rate of recurrence. Effective non-surgical treatment is therefore highly desirable.Areas covered: This review discusses the pathogenesis of CSDH and drugs that have been used to treat CSDH either as monotherapy or an adjuvant to surgery, including controlled clinical trials.Expert opinion: The pathophysiology of CSDH remains poorly understood. Developing effective drug treatments is therefore challenging. Most drugs discussed in this review are evaluated in small clinical studies without sufficient sample size and controls for confounding variables. More controlled clinical trials are therefore needed to carefully evaluate drugs for the non-surgical treatment of CSDH, especially for drugs targeting specific pathogenic pathways of CSDH. PMID: 31957506 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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INTRODUCTION Admission computed tomography (CT) is a widely used diagnostic tool for patients with pelvic fractures. In this pilot study, we hypothesized that pelvic hematoma volumes derived using a rapid automated deep learning-based quantitative visualization and measurement algorithm predict interventions and outcomes including (a) need for angioembolization (AE), pelvic packing (PP), or massive transfusion (MT), and (b) in-hospital mortality. METHODS We performed a single-institution retrospective analysis of 253 patients with bleeding pelvic fractures who underwent admission abdominopelvic trauma CT between 2008 ...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
Tozuda, a company based in Philadelphia, has developed a head impact sensor that can be attached to a sports helmet, such as those worn by football or hockey players, and which will indicate if a dangerous impact has occurred. The sensor undergoes a ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Sports Medicine Source Type: blogs
Beca Glyn, 26, fell of the bike on her family farm in North Wales in March 2018. Her sense of taste and smell was damaged as a result of the head injury.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionPatients with reactive pupils and/or mild to moderate GCS may have benefited from TXA in the CRASH-3 trial because they had less intracranial bleeding at baseline. However, because bleeding occurs soon after injury, treatment delay reduces the benefit of TXA.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
We describe the relationship between Glasgow Coma Scale (GCS) scores at presentation and risk of ci...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study explored associations with mortality in patients with mTBI.Methods: This was a retrospective study of patients with mTBI and controls admitted to six level 1 trauma centers in 1/1/2009-12/31/2013. Mortality data were from the CDC National Death Index. Patients with mTBI were identified by ICD-9 code, Glasgow Coma Scale 13-15, Injury Severity Score (ISS)
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Publication date: Available online 13 February 2020Source: European Journal of RadiologyAuthor(s): Mostafa Alabousi, Vincent M. Mellnick, Rayeh Kashef Al-Ghetaa, Michael N. PatlasAbstractBlunt abdominal trauma often presents a diagnostic challenge. Clinical examination demonstrates low reliability in detecting abdominal injury (16%) when there is a history of head injury or loss of consciousness. This can prove detrimental, as delays in the diagnosis of traumatic bowel injury of 8 hours or less can result in increased morbidity and mortality, as well as prolonged hospitalization. Although hemodynamically unstable pa...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsCurrent TBI outcome prediction models can be improved by the addition of neuromonitoring bedside parameters measured continuously within the first 24  h after the start of neuromonitoring. As these factors might be modifiable by treatment during the admission, testing in a larger (multicenter) data set is warranted.
Source: Neurocritical Care - Category: Neurology Source Type: research
This study evaluated the effect of a five-year school-based campaign (4- to 8-year...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
The reverse shock index (rSI), a ratio of systolic blood pressure (SBP) to heart rate (HR), is used to identify prognosis in trauma patients. Multiplying rSI by Glasgow Coma Scale (rSIG) can possibly predict better in-hospital mortality in patients with tr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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