Pickering stabilized nanocellulose-alginate: A diosgenin-mediated delivery of quinalizarin as a potent cyto-inhibitor in human lung/breast cancer cell lines
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Sevinc Ilkar Erdagi, Fahanwi Asabuwa Ngwabebhoh, Ufuk YildizAbstractThe current study explores the facile fabrication of multilayer self-assembled electrostatic oil-in-water Pickering emulsions (PEs) using quaternized nanocellulose (Q-NC) and diosgenin-conjugate alginate (DGN-ALG) particles as stabilizers to form hydrocolloid nanocarriers. The conditions of formulation such as storage time, pH, temperature and salt effect on the emulsion stability were evaluated. The results deduced showed good emulsion droplet stability over a period of 30 days. Morphological analysis revealed the hydrodynamic sizes of the PE droplets to be spherically shaped with an average diameter of 150 ± 3.51 nm. Creaming index, wettability and critical aggregation concentrations (CAC) as well as chemical characterization of the PEs were examined. In vitro release kinetics of encapsulated quinalizarin as a model drug was investigated with a determined cumulative drug release (CDR) of 89 ± 1.21% in simulated pH blood medium of pH 7.4. In addition, cellular internalization of the PEs was studied via confocal microscopy imaging and showed high cellular uptake. Also, evaluated in vitro cytotoxicity by MTT assay demonstrated excellent anticancer activity in human lung (A549) and breast (MCF-7) cancer cell lines.Graphical abstract
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process]
Condition: Survival, Prosthesis Intervention: Diagnostic Test: Osteopontin Sponsor: Mansoura University Completed
Condition: HER2-positive Breast Cancer Intervention: Drug: [18F]-FDG Sponsor: University of Alabama at Birmingham Not yet recruiting
Conditions: Breast Cancer Female; BRCA1 Mutation; BRCA2 Mutation Intervention: Other: liquid biopsy Sponsors: Centre Jean Perrin; International Cancer Research Group; Institut Max Planck d'optique quantique Not yet recruiting
Condition: Breast Cancer Intervention: Procedure: Sentinel lymph node biopsy Sponsor: Bulent Ecevit University Recruiting
Conditions: Breast Cancer; Cancer Interventions: Drug: Venetoclax; Drug: Capecitabine Sponsor: AbbVie Not yet recruiting
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