Predicting Personalized Risk of Mood Recurrences in Youths and Young Adults With Bipolar Spectrum Disorder

With each recurrence the prognosis of bipolar disorder (BD) worsens, indicating the need to identify the factors associated with increased recurrence risk. The course of BD is heterogenous and although risk factors for recurrence for the group as a whole have been reported in the literature, identification of risk factors for a specific individual are crucial for developing personalized treatments.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New Research Source Type: research

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Authors: Dietrich DE, Bode L, Spannhuth CW, Hecker H, Ludwig H, Emrich HM Abstract BACKGROUND: Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. This called to mind previous evidence for an infectious contribution of BDV-1 to mental disorders. Pilot open trials suggested that BDV-1 infected depressed patients benefitted from antiviral therapy with a licensed drug (amantadine) which also tested sensitive in vitro. Here, we designed a double-blind placebo-controlled randomized clinical trial (RCT) which cross-lin...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Publication date: Available online 19 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Aaron Ettenberg, Kathy Ayala, Jacob T. Krug, Lisette Collins, Matthew S. Mayes, Matthew P.A. FisherAbstractSub-anesthetic doses of ketamine produce an increase in rodent ambulation that is attenuated by co-administration of naturally-occurring lithium (LiN), the drug most commonly employed in the treatment of bipolar illness. As a consequence, ketamine-induced hyperactivity has been proposed as an animal model of manic behavior. The current study employed a modified version of this model to compare the potency of LiN...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
This article outlines the biophysics of electrosurgery and tissue energy sources, including the basic concepts of both modalities. It explores the biophysics of electrodiathermy, including current density, waveforms and electrosurgical circuits. The principles of monopolar and bipolar diathermy are described with reference to the safety issues pertinent to implantable cardiac devices and other implants. Safe application of electrodiathermy in endoscopic and laparoscopic surgery is discussed, exploring potential risks such as direct and capacitance coupling. The principles behind tissue energizers, specifically advanced bip...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Authors: Petrasch-Parwez E, Schöbel A, Benali A, Moinfar Z, Förster E, Brüne M, Juckel G Abstract There is increasing evidence from genetic, biochemical, pharmacological, neuroimaging and post-mortem studies that immunological dysregulation plays a crucial role in the pathogenesis of psychoses. The involvement of microglia in schizophrenia and bipolar disorder (BD) has remained controversial, however, since results from various post-mortem studies are still inconclusive. Here, we analyzed the estimated density of microglia of age-matched individuals with schizophrenia (n = 17), BD (n&th...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Authors: Morton E, Murray G Abstract Sleep problems are highly prevalent in bipolar disorder (BD) and constitute an important therapeutic focus in this population: They are highly impairing and distressing, are an area of subjective importance to consumers, and likely play a role in predicting/triggering mood episodes. The aim of this review is to orient psychologists and psychotherapists to current research relevant to their clinical practice with people with BD, including (a) the prevalence and presentation of sleep problems, (b) the impacts and correlates of impaired sleep, and (c) the relationship between sleep...
Source: Clinical Psychology and Psychotherapy - Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research
Publication date: Available online 19 February 2020Source: NeuroImage: ClinicalAuthor(s): Nuno Madeira, João Valente Duarte, Ricardo Martins, Gabriel Nascimento Costa, António Macedo, Miguel Castelo-BrancoAbstractSchizophrenia is believed to be a neurodevelopmental disease with high heritability. Differential diagnosis is often challenging, especially in early phases, namely with other psychotic disorders or even mood disorders. such as bipolar disorder with psychotic symptoms. Key pathophysiological changes separating these two classical psychoses remain poorly understood, and current evidence favors a more ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Konstantinos Palikaras, Nektarios TavernarakisAbstractMaintenance of synaptic homeostasis is a challenging task, due to the intricate spatial organization and intense activity of synapses. Typically, synapses are located far away from the neuronal cell body, where they orchestrate neuronal signalling and communication, through neurotransmitter release. Stationary mitochondria provide energy required for synaptic vesicle cycling, and preserve ionic balance by buffering intercellular calcium at synapses. Thus, synaptic h...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
AbstractBackgroundLimited studies are available on the clinical significance of left ventricular lead polarity in patients undergoing cardiac resynchronization (CRT), with a recent study suggesting better outcomes with LV true bipolar pacing.ObjectivesWe aimed to determine whether True ‐Bipolar LV pacing is associated with reduced mortality in a large, real‐life CRT cohort, followed by remote monitoring.MethodsWe analyzed de ‐identified device data from CRT patients followed by the Boston Scientific LATITUDE remote monitoring database system. Patients with LV bipolar leads paced between the LV ring and LV tip were id...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
Conditions:   Agitation Associated With Bipolar Disorder;   Agitation,Psychomotor;   Bipolar Disorder Interventions:   Drug: Sublingual film containing Dexmedetomidine (BXCL501);   Drug: Placebo Film Sponsors:   BioXcel Therapeutics Inc;   Cognitive Research Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Prostate Hyperplasia Intervention:   Procedure: Holmium laser enucleation of the prostate versus bipolar transurethral enucleation of the prostate in management of benign prostatic hyperplasia Sponsor:   Ahmed Maher Gamil Ahmed Higazy Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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