miR-1180 promotes cardiomyocyte cell cycle reentry after injury through the NKIRAS2-NF κB pathway.

miR-1180 promotes cardiomyocyte cell cycle reentry after injury through the NKIRAS2-NFκB pathway. Biochem Cell Biol. 2020 Jan 19;: Authors: Ding Y, Bi L, Wang J Abstract Heart failure (HF) is associated with considerable symptom burden and impairment for human health, including quality of life and physical functioning. Previous studies have indicated that miRNAs have important roles in regulating HF development. miR-1180 is influential in the proliferation, migration, invasion and chemoresistance of cancer cells; however, the underlying mechanism and role of miR‑1180 in cardiomyocytes remains unclear. In the present study, we found that miR-1180 promoted cell activity and cell cycle process by driving energy generation through the NKIRAS2, which declined over time during development process. miR‑1180 expression is down-regulated in a H/R-induced cells and that miR‑1180 mimics markedly weakened myocardial injury and cell apoptosis. In addition, miR-1180 regulates the NFκB pathway through NKIRAS2 in cardiomyocytes. These findings suggest that miR-1180 maybe a novel therapeutic target for cardiomyocyte cell cycle reentry and cardiac repair following myocardial injury in future. PMID: 31955591 [PubMed - as supplied by publisher]
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research