Supplemental Cardioplegia During Donor Heart Implantation: A Systematic Review and Meta-Analysis

Publication date: Available online 21 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Roberto V.P. Ribeiro, Jan O. Friedrich, Maral Ouzounian, Terrance Yau, Jessica Lee, Bobby Yanagawa, Canadian Cardiovascular Surgery Meta-Analysis Working GroupBackgroundThe optimal donor heart preservation and management strategy during heart transplantation remains controversial. Here, we perform a systematic review and meta-analysis of the effect of supplemental cardioplegia administration during donor heart implant for transplantation.MethodsWe searched MEDLINE and EMBASE databases until February 2019 for studies comparing patients who received transplants with the donor heart given supplemental cardioplegia or not. Data was extracted by two independent investigators. The main outcomes were early morbidity and mortality.ResultsSeven retrospective observational studies (four comparing to historical controls) and 3 randomized controlled trials enrolling 1125 patients were included. Supplemental cardioplegia included crystalloid, and blood cardioplegia given continuous retrograde or as terminal “hot shots”. Supplemental cardioplegia was associated with improved early mortality (risk ratio [RR]:0.55; 95%CI:0.35 to 0.87; p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Heart Transplant Infection;   CMV Infection Intervention:   Diagnostic Test: ELISPOT IFN-γ assay Sponsors:   Hospital Universitari de Bellvitge;   Instituto de Salud Carlos III;   Sociedad Española de Cardiología Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Heart Transplant Infection;   CMV Infection Intervention:   Diagnostic Test: ELISPOT IFN-γ assay Sponsors:   Hospital Universitari de Bellvitge;   Instituto de Salud Carlos III;   Sociedad Española de Cardiología Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
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