Type B Aortic Dissection in Young Individuals With Confirmed and Presumed Heritable Thoracic Aortic Disease

Publication date: February 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 2Author(s): Sherene Shalhub, Mary J. Roman, Kim A. Eagle, Scott A. LeMaire, Qianzi Zhang, Artur Evangelista, Dianna M. Milewicz, Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) ConsortiumBackgroundTo investigate clinical course of patients with type B aortic dissection (TBAD) occurring at a young age with confirmed or suspected heritable thoracic aortic disease.MethodsIndividuals with TBAD occurring at an age
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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Publication date: Available online 31 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Sherene Shalhub, Mary J. Roman, Kim A. Eagle, Scott A. LeMaire, Qianzi Zhang, Artur Evangelista, Dianna M. Milewicz, Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) ConsortiumAbstractBackgroundTo investigate clinical course of patients with TBAD occurring at a young age with confirmed or suspected heritable thoracic aortic diseaseMethodsIndividuals with TBAD occurring at an age
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Guillaume Goudot1, Tristan Mirault2,3, Patrick Bruneval2,4, Gilles Soulat5, Mathieu Pernot1 and Emmanuel Messas2,3* 1INSERM U1273, ESPCI Paris, CNRS FRE 2031, Physics for Medicine Paris, PSL Research University, Paris, France 2Centre de Référence des Maladies Vasculaires Rares, Hôpital Européen Georges-Pompidou, Assistance Publique – Hôpitaux de Paris (APHP), Paris, France 3INSERM U970 PARCC, Paris Descartes University – Sorbonne Paris Cité University, Paris, France 4Service d’Anatomie Pathologique, Hôpital Européen Georges-Pompidou, Assistanc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Outcomes of Early-Onset Acute Type A Aortic Dissection - Influence of Etiologic Factors. Circ J. 2018 Dec 22;: Authors: Kimura N, Aizawa K, Kawahito K, Itagaki R, Yamaguchi A, Misawa Y, Siepe M, Czerny M, Beyersdorf F, Kari FA, Rylski B Abstract BACKGROUND: Outcomes of early-onset acute type A aortic dissection (ATAAD) associated with Marfan syndrome (MFS) are known, but not with other etiologies. Methods and Results: ATAAD patients from 2 centers (n=1,001) were divided into 2 groups: age ≤45 years (n=93) and age>45 years (n=908). Although in-hospital death and 10-year survival were simila...
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
Abstract Thoracic aortopathy - especially aneurysm, dissection, and rupture - is responsible for significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk factors for such conditions and they contribute, respectively, to increasing the mechanical stress on the wall and increasing its structural vulnerability. Select genetic mutations also predispose to these lethal conditions, and the collection of known mutations suggests that dysfunctional mechanosensing and mechanoregulation of extracellular matrix may contribute to pathogenesis and disease progression. In the absence of a well-a...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
CONCLUSIONS: AD is an emergency in which diagnosis and timely management are essential to improve prognosis. In the sample presented here, a significant association was found in patients with a history of Marfan syndrome and abdominal aneurysms with dissections according to the Stanford classification. The rest of the independent variables did not show any significant association, probably related to the size of the sample. PMID: 30017466 [PubMed - as supplied by publisher]
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
AbstractObjectivesActin, alpha-2, smooth muscle, aorta (ACTA2) mutations are one of the major causes of familial thoracic aortic aneurysms and dissections. The aim of this study was to review our clinical results of young adult patients with aortic disease caused by ACTA2 mutations.MethodsWe reviewed the medical records of 251 patients (
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
A variety of syndromic diseases such as Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve with aneurysm along with risk factors of smoking and hypertension result in ascending aortic aneurysms and dissections. Historically, a complicated variety of terms have been used to describe a range of histopathologies that are present in resected specimens. As a result, no consistent patterns of histopathology have been reported. We used the recent SCVP/AECVP consensus statement on nomenclature and diagnostic criteria for noninflammatory aortic disease to blindly evaluate 148 surgically resected specimens.
Source: Cardiovascular Pathology - Category: Cardiology Authors: Source Type: research
We present three cases of thoracic aortic aneurysms caused by giant cell aortitis. Thoracic aortic aneurysms are common and usually related to hypertension, a bicuspid aortic valve or connective tissue diseases such as Marfan syndrome. Our report serves as a reminder that giant cell aortitis is an unusual yet very important cause of thoracic aortic aneurysm.
Source: JRSM - Category: UK Health Authors: Tags: Grand Round Source Type: research
We present three cases of thoracic aortic aneurysms caused by giant cell aortitis. Thoracic aortic aneurysms are common and usually related to hypertension, a bicuspid aortic valve or connective tissue diseases such as Marfan syndrome. Our report serves as a reminder that giant cell aortitis is an unusual yet very important cause of thoracic aortic aneurysm. PMID: 27222365 [PubMed - as supplied by publisher]
Source: J R Soc Med AND (has... - Category: Journals (General) Authors: Tags: J R Soc Med Source Type: research
Ascending thoracic aortic aneurysm (ATAA) is described at tissue level by medial degeneration and biomechanical weakening of the aneurysmal wall, ultimately leading to aortic dilatation and failure [1]. Elective surgery is indicated when the aortic diameter exceeds 5.5 cm since the yearly risk of dissection or rupture rises from 3% to 7% with aneurysms>6 cm [2]. Predisposing risk factors include poorly controlled hypertension, Marfan syndrome and importantly bicuspid aortic valve (BAV). Indeed, patients with BAV have a 9-fold increased risk of developing ATAA-related fatal complications compared with individua...
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Source Type: research
More News: Abdominal Aneurysm Repair | Aortic Aneurysm | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Gastroschisis Repair | Genetics | Heart | Hypertension | Marfan Syndrome