A Rare Pulmonary Artery Sarcoma Masquerading as Pulmonary Embolus

We present the case of a 46-year-old woman with a presumed diagnosis of multiple unprovoked pulmonary emboli. Her cardiorespiratory function continued to deteriorate despite optimal medical therapy. At surgical thrombectomy she was identified to have an intimal soft tissue lesion arising from the right pulmonary artery. This lesion was subsequently diagnosed as a pulmonary artery sarcoma, a rare neoplasm that carries a poor prognosis. It typically presents at an advanced stage with pulmonary vascular obstruction. Surgical debulking is the mainstay of therapy to restore ventilation perfusion mismatching and relieve right-sided heart strain. Median survival of these patients is 20 months with adjuvant chemoradiotherapy. At 9 months after surgery, she has undergone 6 cycles of chemotherapy and has stable disease with no metastases.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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ConclusionsShe needed radical resection according to the actual situation. However, her age restricted her tolerance to general anesthesia; relatively conservative treatment options are available to ensure a high quality of life. The treatment of primary tumor resection combined with bladder perfusion chemotherapy is feasible. This case highlights the importance of the dissemination of new cases and optimizing primary urethral cancer diagnosis to obtain an effective treatment.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ConclusionsES have a high rate of recurrence, particularly as locoregional relapse. Locally advanced disease, size larger than 5  cm, R1 surgical margins were identified as a poor-prognosis factors.Legal entity responsible for the studyPerrin Christophe.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
We present a case of a 46 year old female with a presumed diagnosis of multiple unprovoked pulmonary emboli. She continued to deteriorate from a cardiorespiratory point of view despite optimal medical therapy. At surgical thrombectomy she was identified to have a intimal soft tissue lesion arising from the right pulmonary artery. This lesion was subsequently diagnosed as a pulmonary artery sarcoma. At nine months post surgery she has undergone six cycles of chemotherapy and has stable disease with no metastases.Pulmonary artery sarcoma (PAS) is a rare neoplasm which carries a poor prognosis. It typically presents at an adv...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We present a case of a 46 year old female with a presumed diagnosis of multiple unprovoked pulmonary emboli. She continued to deteriorate from a cardiorespiratory point of view despite optimal medical therapy. At surgical thrombectomy she was identified to have a intimal soft tissue lesion arising from the right pulmonary artery. This lesion was subsequently diagnosed as a pulmonary artery sarcoma. At nine months post surgery she has undergone six cycles of chemotherapy and has stable disease with no metastases. Pulmonary artery sarcoma (PAS) is a rare neoplasm which carries a poor prognosis. It typically presents at an ad...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Conclusion: Fat fraction on MRI corresponded to fat content on histology and therefore contributes to lesion characterization. Measurement repeatability was excellent for ADC; this parameter increased significantly post-radiotherapy even in disease categorized as stable by size criteria, and corresponded to cellularity on histology. ADC can be utilized for characterizing and assessing response in heterogeneous retroperitoneal sarcomas. Introduction Soft-tissue sarcomas are often highly heterogeneous tumors with variable components that can include cellular tumor, fat, necrosis, and cystic change. In many soft-tissue ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Viral ILP augments the response to PD-1 blockade, transforming this locoregional therapy into a potentially effective systemic treatment for sarcoma and warrants translational evaluation. PMID: 30885937 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
We report a case of ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor and accompanied by nodular histiocytic aggregates in the greater omentum. Patient concerns: A 60-year-old postmenopausal woman was presented with a history of one month of lower abdominal discomfort, abdominal distension, nausea, and vomiting. A physical examination revealed a hard, palpable mass with mild tenderness in her right lower abdomen. Diagnoses: The mucinous tumor was solid and cystic and contained benign, borderline, and malignant elements. Within the solid areas, two nodules representing ple...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
AbstractThe goals of treatment for soft tissue sarcoma (STS) of the extremities are local tumor control, preservation of limb function and reduction of the risk of distant metastasis. The standard treatment for STS of the limbs is wide local excision with histologically negative margins and, in the majority of cases, adjuvant radiotherapy. In the case of locally advanced tumors, this might not be feasible, especially when the tumor is located at the periphery of the limb, or tumor infiltration, encasement or fixation of motor nerves, major vessels or bones has occurred, in which case, amputation may be necessary. The aim o...
Source: Hellenic Journal of Surgery - Category: Surgery Source Type: research
AbstractBackgroundInduction chemotherapy by isolated limb perfusion (ILP) with melphalan and tumour necrosis factor- α is an effective strategy to facilitate limb-conserving surgery in locally advanced extremity sarcoma. In a comparison of cohorts matched for grade, size and surgical resectability, we compared the outcome of patients undergoing induction ILP prior to limb-conserving surgery and selective post-ope rative radiotherapy with patients undergoing limb-conserving surgery and routine post-operative radiotherapy.MethodsPatients with primary, grade 2/3 sarcomas of the lower limbs over 10  cm in size were ...
Source: Clinical Sarcoma Research - Category: Cancer & Oncology Source Type: research
ConclusionsTo our knowledge, this is the first report of activity of soft tissue sarcoma-oriented chemotherapy in advanced OFMT.
Source: Clinical Sarcoma Research - Category: Cancer & Oncology Source Type: research
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