Inhibition mechanism of cardamom essential oil on methicillin-resistant Staphylococcus aureus biofilm

Publication date: Available online 20 January 2020Source: LWTAuthor(s): Haiying Cui, Chenghui Zhang, Changzhu Li, Lin LinAbstractIn recent years, studies have found that in addition to nosocomial infections, methicillin-resistant Staphylococcus aureus (MRSA) can even cause community-associated infections, and MRSA spreads through food and animal that produce products in the community. In addition, MRSA can colonize the surface of food and food container and form biofilms by secreting extracellular polymers, leading to cross-infection. Cardamom essential oil has been found to be highly active against MRSA. Therefore, this study aimed to investigate the inhibitory effect of cardamom essential oil on MRSA biofilm and its mechanism. The semi-quantitative test results of crystal violet and the removal of MRSA biofilm on different food container materials show that cardamom essential oil can effectively remove MRSA biofilm and can be applied to the surface of food container materials. Meanwhile, the inhibition mechanism of cardamom essential oil on MRSA biofilm was studied by measuring the metabolic activity, extracellular polymer content and relative expression of MRSA biofilm formation related genes. Based on results, it is presumed that cardamom essential oil can function to scavenge MRSA biofilm by inhibiting the metabolic activity of bacteria, inhibiting the formation of extracellular polymers, and regulating the expression of genes involved in biofilm formation.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research

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(American Chemical Society) Public health agencies worldwide have identified antibiotic resistance of disease-causing bacteria as one of humanity's most critical challenges. However, scientists haven't discovered a new class of antibiotics in more than 30 years. Now, researchers reporting in ACS Infectious Diseases have uncovered the hidden antibiotic potential of a non-psychoactive cannabis compound called cannabigerol (CBG), which helped control methicillin-resistant Staphylococcus aureus (MRSA) infections in mice.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
IJERPH, Vol. 17, Pages 1500: Assessing the Potential Impact of a Long‐Acting Skin Disinfectant in the Prevention of Methicillin‐ Resistant Staphylococcus aureus Transmission International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051500 Authors: Short Mietchen Lofgren Healthcare‐associated transmission of methicillin‐resistant Staphylococcus aureus (MRSA)remains a persistent problem. The use of chlorhexidine gluconate (CHG) as a means of decolonizingpatients, either through targeted decolonization or daily bathing, is frequently used to supplementother interventions. ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionThere was a significant association of antibiotic therapy and age on S. aureus carriage profiles in CF patients indicating that antibiotic therapy prevents acquisition of new clones, while during aging of patients with persisting S. aureus, dominant clones were selected and mutations in the spa-repeat region accumulated.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Prosthetic joint infection (PJI) is one of the most devastating failures in total joint replacement (TJR). Infections are becoming difficult to treat due to the emergence of multi-drug resistant bacteria. These bacteria produce biofilm on the implant surface, rendering many antibiotics ineffective by compromising drug diffusion and penetration into the infected area. With the introduction of new antibiotics there is a need to create benchmark data from the traditional antibiotic loaded bone cements. Vancomycin, one of the commonly used antibiotics, shows activity against Methicillin-resistant Staphylococc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
AbstractThe aim of the present study was to identify predictors of fatality among patients withS. aureus infections requiring hospitalization. Cases hospitalized withS. aureus infections at the University General Hospital of Patras, Greece, during a 4-year period (2013 –2016) were studied.mecA, lukS/lukF-PV (Panton-Valentine leukocidin, PVL),tst (toxic shock syndrome toxin),fnbA (fibronectin-binding protein A),eta, andetb (epidermolytic toxins) genes ’ carriage was detected by PCR in 149 selected patients. Among 464 patients, 346 were included (118 with missing data). Primary bacteremia predominated (44.2%), fo...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly the international clones/sequence types (STs) of most pathogens emerged and disseminated during the last three decades. Strong experimental evidence from multiple laboratories indicate that diverse fitness cost associated with high-level resistance to fluoroquinolones contributed to the selection and promotion of the international clones/STs of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA), extended-spectrum β-lactamase-(ESBL)-producing Klebsiella pneumoniae, ESBL-produci...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Molecular typing methods are useful for rapid detection and control of a disease. Recently, the use of high-resolution melting (HRM) for spa typing of MRSA isolates were reported. This technique is rapid, inexpen...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Hospital InfectionAuthor(s): Sarah Jolivet, Isabelle Lolom, Sébastien Bailly, Lila Bouadma, Brice Lortat-Jacob, Philippe Montravers, Laurence Armand-Lefevre, Jean-François Timsit, Jean-Christophe LucetSummaryBackgroundColonisation pressure is a risk factor for intensive care unit (ICU)-acquired multidrug-resistant organisms (MDROs).AimTo measure the long-term respective impact of colonisation pressure on ICU-acquired extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) and meticillin resistant Staphylococcus aureus (MRS...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 21 February 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Khamis Al-Dhafri, Chai Lay Ching, Saiful Anuar KarsaniAbstractThe emergence of antibiotic resistance among bacteria leads to the urge of finding an alternative solution. Therefore, antimicrobial peptides (AMPs) have emerged as a promisingly new group of therapeutic agents for managing infectious diseases. This research was designed to explore the potency of antimicrobial peptides from Omani Juniperus seravschanica plant and their mode of action. The isolated AMPs showed to have inhibitory activity towards pathog...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Authors: Blakiston MR, Freeman JT Abstract AIMS: National responses to antimicrobial resistance (AMR) require an understanding of the factors driving its development and spread. Research to date has primarily focused on determining individual-level risk factors for AMR-associated infections. However, additional insights may be gained by investigating exposures associated with AMR variation at the population level. METHODS: We used an ecological study design to describe the association between the incidence rate of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase producin...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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