Scalogram based Prediction Model for Respiratory disorders using Optimized Convolutional Neural Networks

Publication date: Available online 20 January 2020Source: Artificial Intelligence in MedicineAuthor(s): S. Jayalakshmy, Gnanou Florence SudhaAbstractAuscultation of the lung is a conventional technique used for diagnosing chronic obstructive pulmonary diseases (COPDs) and lower respiratory infections and disorders in patients. In most of the earlier works, wavelet transforms or spectrograms have been used to analyze the lung sounds. However, an accurate prediction model for respiratory disorders has not been developed so far. In this paper, a pre-trained optimized Alexnet Convolutional Neural Network (CNN) architecture is proposed for predicting respiratory disorders. The proposed approach models the segmented respiratory sound signal into Bump and Morse scalograms from several intrinsic mode functions (IMFs) using empirical mode decomposition (EMD) method. From the extracted intrinsic mode functions, the percentage energy calculated for each wavelet coefficient in the form of scalograms are computed. Subsequently, these scalograms are given as input to the pre-trained optimized CNN model for training and testing. Stochastic gradient descent with momentum (SGDM) and adaptive data momentum (ADAM) optimization algorithms were examined to check the prediction accuracy on the dataset comprising of four classes of lung sounds, normal, crackles (coarse and fine), wheezes (monophonic &polyphonic) and low-pitched wheezes (Rhonchi). On comparison to the baseline method of standard...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

Related Links:

In conclusion, our results suggest that miR-200b may attenuate cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema. PMID: 32070140 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
α1-antitrypsin deficiency (AATD) is a hereditary disorder associated with a risk of developing liver disease and pulmonary emphysema, and other chronic respiratory disorders (mainly asthma and bronchiectasis); Z variant is the commonest deficient variant of AAT. Determining AAT concentration in serum or plasma and identifying allelic variants by phenotyping or genotyping are fundamental in the diagnosis of AATD. Initial evaluation and annual follow-up measurement of lung function, including post-bronchodilator forced expiratory volume in 1 s and gas transfer inform on disease progression. Lung densitometry is th...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Genetics Review Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
f M Abstract Chronic lung diseases (CLDs), such as COPD, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and present a major health and financial burden on patients and society. Effective treatments are scarce and relevant human model systems to effectively study CLD pathomechanisms and thus discover and validate potential new targets and therapies are needed. Precision-cut lung slices (PCLS) from healthy and diseased human tissue represent one promising tool which can closely recapitulate the complexity of the lung's native environment, and recently, improved methodo...
Source: American Journal of Respiratory Cell and Molecular Biology - Category: Molecular Biology Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
UNDERWEIGHT PATIENTS WITH CYSTIC FIBROSIS HAVE ACCEPTABLE SURVIVAL AFTER LUNG TRANSPLANTATION: A UNOS REGISTRY STUDY. Chest. 2020 Jan 17;: Authors: Ramos KJ, Kapnadak SG, Bradford MC, Somayaji R, Morrell ED, Pilewski JM, Lease ED, Mulligan MS, Aitken ML, Gries CJ, Goss CH Abstract BACKGROUND: Reduced body mass index (BMI) is an absolute contraindication for lung transplantation (LTx) at most centers in the United States (US). Our objective was to quantify post-LTx survival of moderate-to-severely underweight cystic fibrosis (CF) patients (BMI
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
In conclusion, tracheal stenosis patients have significant comorbidities that increase the risks after resection. However, these patients should still be considered for surgery for an improved quality of life and eventual resolution of severe stenosis. PMID: 32063757 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
Conditions:   Advanced Lung Disease;   COPD;   Interstitial Lung Disease Intervention:   Sponsor:   Klaus Kenn Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
‘First step’ to better outcomes for cystic fibrosis Related items fromOnMedica Lung experts call for ‘national plan for lung cancer’ Smokers ’ lungs should remain as transplant option COPD patients need better tailored care Antibiotic fails to improve lung function in children with CF Sweet and fruity e-cigs linked to prolonged teenage vaping
Source: OnMedica Latest News - Category: UK Health Source Type: news
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Rationale: The role of pre- and post-lung transplant rehabilitation is to maintain or improve exercise tolerance, lung mechanics, peripheral and respiratory muscle function.Aims: Follow-up on the changes of functional and quality-of-life markers in lung transplant patients (LuTx) after pre- and post-LuTx pulmonary rehabilitation.Materials and Methods: 70 patients (46 COPD FEV1:21±5 %pred, 19 IPF TLC: 42±13 %pred, 4 bronchiectasis FEV1: 28±4 %pred, alveolitis fibrotisans TLC: 31 %pred) participated in a pre- and 15 took part in a post-LuTx rehabilitation program (primary diagnosis: 10 COPD, 5 IPF). The ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and chronic care Source Type: research
More News: Bioinformatics | Chronic Obstructive Pulmonary | Lung Transplant | Respiratory Medicine | Training | Universities & Medical Training