Cyclic RNA hsa_circ_0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA-589-5p.

CONCLUSIONS: The circular RNA hsa_circ_0091017 can inhibit the proliferation, migration and invasiveness of BCa cells by regulating the expression of microRNA-589-5p. PMID: 31957821 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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ConclusionsThe significant association between both objective and subjective FT and HRQoL highlights the importance of reducing FT among urologic cancer patients. Subjective FT was found to have a greater negative impact on HRQoL.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Current evidence indicates that minimally invasive approaches could be considered as a feasible and safe alternative to ORC when performed by experienced surgeons in selected patients. Notably, RARC may be more suitable for RC with extracorporeal urinary diversion. Larger well-designed trials are still needed to confirm these findings due to the observational nature of most studies. PMID: 32083418 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: Regnier P, De Luca V, Brunelle S, Sfumato P, Walz J, Rybikowski S, Maubon T, Branger N, Fakhfakh S, Durand M, Gravis G, Pignot G Abstract BACKGROUND: Sarcopenia is suspected to influence the complication rates in patients undergoing radical cystectomy (RC). The aim of our study was to assess variations in sarcopenia in patients scheduled for neoadjuvant cisplatin-based chemotherapy (NAC) and RC for muscle invasive bladder cancer (MIBC) and to explore the impact of sarcopenia on complications linked to NAC or surgery. METHODS: Between 2012 and 2017, 82 consecutive patients who underwent NAC and RC for c...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
ConclusionsBy reference to the significant difference between T-AOC in patients and healthy controls, our results strongly suggest a low level of T-AOC in patients with BC. The obtained changes in T-AOC before and after management with vitamin E recommended additional consideration associates with different stages and grade of tumor in patients with BC.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions This review highlights the breadth of strategies that aim to preserve a patient ’ s bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the field towards patient-tailored care.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions Despite BC relatively low incidence, it still represents a significant social economic burden in Brazil, as it presents with recurrent episodes that might require multiple hospitalizations and surgical treatment. The set of data collected might suggest that population access to health care has improved between 2008-2017.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development re...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
A new study conducted by researchers from the United Nations health agency revealed that bladder cancer mutations can be detected in urine up to 10 years before clinically diagnosing the disease.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
ConclusionXPA and XPG polymorphism might be significant risk factor in North-Indian population and acquisition of these genetic variations together with smoking might trigger urinary bladder cancer development. Further pathway based studies on larger population are warranted to confirm our conclusion.Clinical significanceThe XPA-A23G and XPG-Asp1104His genetic variations could be used as UBC susceptibility markers in North-Indian population. These SNPs could be useful biomarkers for UBC prognosis or diagnosis and thus could help in enhancing the survival rates of UBC patients and improving patient care. However, before mak...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
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