Triple-Negative Breast Cancer Tumor Stroma Plays Big Role in Bone Metastases

In order for malignancies to establish in metastatic sites, cancer cells must acquire attributes of those sites; specifically how this occurs in many cancers is relatively unknown, but a new study implicates the stroma of certain breast cancer tumors in the development of bone metastases.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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The objective of this paper is to investigate the detectability of breast tumors having various histological types in excised breast tissues of total mastectomy. The tumor images measured by a portable impulse-radio-ultra-wideband (IR-UWB)-radar-based breast cancer detector are compared with both pathological images and images of dedicated breast positron emission tomography. It is found that the detector can detect invasive-ductal-carcinomas and extensive intraductal component in the dense breast. The density of the breast has a correlation to the effective permittivity derived from the reconstructed confocal images. The ...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
We examined the influence of the patient's surgeon on patient preferences. RESULTS: Our retrospective analyses examined a study population that had similar risk profiles (age, family history of breast cancer, T category on tumor-node-metastasis staging system, tumor size, physical examination findings), surgeons consulting on similar patient types, and managed by surgeons with similar surgical performance patterns (case volumes, reexcision rates, number of reoperations, and ability to meet patient's expectations). Patients who preferred mastectomy were strongly influenced by tumor size (p
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Publication date: 15 October 2019Source: Sensors and Actuators B: Chemical, Volume 297Author(s): Xin Xiong, Yao Zhang, YinFang Wang, HaiFeng Sha, Nengqin JiaAbstractBy virtue of the metal organic framework UiO-66-NH2, an ingenious electrochemiluminescence immunosensor was successfully constructed for subtle exploration of the breast cancer biomarker CA 15-3. In this protocol, Ru(bpy)3Cl2·6H2O (Ru(bpy)32+), as a conventional luminescent reagent, provides a stable and strong luminescent signal. The UiO-66-NH2 serves as a carrier to provide a large specific surface area for enhancing the electrochemical luminescence si...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 17 July 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Sekar Vijayakumar, Balasubramanian Malaikozhundan, Kandasamy Saravanakumar, Esteban F. Durán-Lara, Myeong-Hyeon Wang, Baskaralingam VaseeharanAbstractFacile and low cost garlic clove extract based silver nanoparticles was synthesized and its broad spectrum of therapeutic activity including antibiofilm, antiparasitic and anti-breast cancer activity was evaluated. The synthesized garlic‑silver nanoparticles (G-AgNPs) were characterized by various physico-chemical techniques. G-AgNPs showed good opti...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
71 yo, history of single-lung transplant with T1N1 triple negative breast cancer. immediate surgery (ie no neoadjuvant therapy). s/p full ax dissection (11 nodes) - final path with single positive node and associated ECE. Would anyone treat axilla in this situation? If it matters the transplanted lung is on the right and the cancer was on the left.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
This week, the Food and Drug Administration (FDA) gave the green light approval to Bayer AG ’s gadobutrol (Gadavist), a gadolinium-based contrast agent (GBCA) used in cardiac MRI procedures for patients with known or suspected coronary artery disease. It’s the first and only approved agent for this type of procedure. “We now have an approved contrast agent for use in cardiac MRI to assess perfusion and late gadolinium enhancement in less than 1 hour, ” saidScott Flamm, MD who co-authored a statement on using the GBCA in myocardial perfusion studies. Gadavist is also used to evaluate t...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Breast cancer causes high mortality among females worldwide. Bufalin has recently been shown to trigger tumor cell death, although the mechanism of cytotoxicity remains unclear. The cytotoxicity of bufalin in breast cancer cells was examined using an MTT assay. The modes of death and intracellular reactive oxygen species production were measured by flow cytometry. We also observed cellular morphologic changes by Hoechst 33342 and propidium iodide staining and transmission electron microscopy. Western blotting was performed to determine the expression levels of related proteins. Our results showed that bufalin reduced cellu...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Abdolhossien Miri, Nafiseh Mahdinejad, Omolbanin Ebrahimy, Mehrdad Khatami, Mina SaraniAbstractZinc oxide nanoparticles (ZnO-NPs) are multifunctional oxide metal nanoparticles that have been considered by many due to their unique properties including UV filtration, semiconducting, antimicrobial, antifungal, and photocatalytic activity. In the present study, ZnO-NPs have been synthesized from Zn(SO4)·7H2O through the use of “green synthesis” method that utilizes Prosopis farcta aqueous extract. The characteri...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 18 July 2019Source: NeurocomputingAuthor(s): Runze Wang, Yide Ma, Wenhao Sun, Yanan Guo, Wendao Wang, Yunliang Qi, Xiaonan GongAbstractMass segmentation in mammograms is an important and challenging topic in breast cancer computer-aided diagnosis. In this work, we propose a novel multi-level nested pyramid network (MNPNet) for dealing with the limitations of intra-class inconsistency and inter-class indistinction that commonly existed in mass segmentation in mammograms. The MNPNet includes an encoder and a decoder. The former encodes contextual information, low-level detail information, a...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Condition:   Breast Cancer Interventions:   Device: Armeo®Power;   Other: Conventional rehabilitation protocol Sponsor:   Barretos Cancer Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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