Protein-stabilized gold nanoclusters for PDT: ROS and singlet oxygen generation
Publication date: Available online 20 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Vilius Poderys, Greta Jarockyte, Saulius Bagdonas, Vitalijus Karabanovas, Ricardas RotomskisAbstractSuitable properties as well as eco-friendly synthesis of photoluminescent Au nanoclusters (NCs) make them promising compounds for biomedical diagnostics and visualization applications. However, the potential photochemical activity of such agents on cancerous cells is largely unknown. The nanoclusters (BSA-Au NCs) were synthetized in the presence of BSA (an average hydrodynamic diameter was about 9.4 nm, while the size of the metal cluster was
Conclusions: Docetaxel and epirubicin neoadjuvant chemotherapy showed a good response in locally advanced breast cancer. Pretreatment Ki-67 and change of Ki-67 may play a role as predictive factor for response to neoadjuvant chemotherapy. PMID: 32069523 [PubMed - as supplied by publisher]
Condition: Primary Breast Cancer Intervention: Diagnostic Test: SPECT Sponsors: Tomsk National Research Medical Center of the Russian Academy of Sciences; Institute of Bioorganic Chemistry, Russian Academy of Sciences; Uppsala University Enrolling by invitation
Condition: Breast Neoplasms Intervention: Drug: DZD3969 Sponsor: Dizal (Jiangsu) Pharmaceutical Co., Ltd. Not yet recruiting
Condition: Early Hormone Receptor-positive Breast Cancer Intervention: Drug: Chemotherapy Drugs, Cancer Sponsor: Gencurix, Inc. Recruiting
To determine the relationship of ablation margin with overall survival (OS), time to progression (TTP) and local recurrence after percutaneous thermal ablation of liver, lung and bone/soft tissue metastases from oligometastatic breast cancer (BC).
To evaluate safety and efficacy of transarterial hepatic Y90 radioembolization in patients with breast cancer liver metastases.
To determine the relationship of radiation dose to imaging response, survival, and toxicity after radioembolization (RE) of liver metastasis from breast cancer.
To perform a Phase I veterinary clinical trial with a low-cost, carbon-dioxide-based, passive thaw cryoablation device1 as proof-of-principle for application in pets and translation to third-world treatment of breast cancer.
The mobilization of the immune system as a therapeutic strategy has emerged as a transformative approach to the treatment of cancer. Intratumoral injection of plasmid IL-12, tavokinogene telseplasmid (TAVO), and co-localized reversible electroporation has demonstrated safe and promising results in the nearly 200 patients enrolled in trials for melanoma, breast cancer, and SCCHN. This current delivery platform uses an applicator capable of reaching lesions no more than 1.5 cm at or below the skin.
ConclusionsApplying the Kaiser score to breast MRI allows stratifying the risk of breast cancer in lesions that present as suspicious calcifications on mammography and may thus avoid unnecessary breast biopsies.Key Points• The Kaiser score is a helpful clinical decision tool for distinguishing malignant from benign breast lesions that present as calcifications on mammography.• Application of the Kaiser score may obviate 58.3–65.3% of unnecessary stereotactic biopsies of suspicious calcifications.• High Kaiser scores predict breast cancer with high specificity, aiding clinical decision-making with regar...